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BENFLUOREX
SynDRA canonical compound SYN0007903 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Primary target(s) | HMGCR |
|---|
| Mechanism of action | Gluconeogenesis inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- Gluconeogenesis inhibitor
- SOAT1 INHIBITOR
- Acyl coenzyme A:cholesterol acyltransferase 1 inhibitor
- HNF4A AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1A
- NR1I2
- HTR2B
- HTR2C
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- KCNH2
- HTR2A
- DRD3
- OPRK1
- OPRD1
- NR3C1
- MAOA
- NPY1R
- MLNR
- MC3R
- PDE3A
- HTR3A
- OPRM1
- ADORA1
- PDE4D
- PGR
- PTH1R
- SAMHD1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- SMAD3
- SMPD1
- TBXA2R
- TDP1
- USP1
- PTGS2
- HRH2
- HRH3
- ADORA2A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- CP3A7
- RAPGEF4
- MDR1
- JUN
- GPR32
- GLI3
- ESRRA
- CP3A4
- ACM1
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- CP19A
- ANDR
- RPGF4
Drug classes
- Anti-Obesity Agents
- Antimetabolites
- Appetite Depressants
- Hypolipidemic Agents
- Lipid Regulating Agents
ATC classes
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- benfluorex methanesulfonate
- benfluorex maleate
- benfluramate
- benfluorex hydrochloride
- Mediaxal
- NSC-757396
- Benfluorex hydrochloride
- Lipophoral
- Balans
- Benfluorex (hydrochloride)
- EINECS 245-801-8
- 2-((1-(3-(Trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate hydrochloride
- NCGC00094832-01
- 2-(alpha-Methyl-3-(trifluoromethyl)phenylethylamino)ethyl benzoat
- DSSTox_CID_25854
- DSSTox_RID_81175
- DSSTox_GSID_45854
- W-110575
- 2-((alpha-Methyl-m-(trifluoromethyl)phenethyl)amino)ethanol benzoate (ester)
- Benfluorex HCl
- 2-{(1-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL}AMINO)ETHYL BENZOATE HYDROCHLORIDE
- Benfluramate
- N-(2-Benzoyloxyethyl)norfenfluramine
- NSC 757396
- RefChem:916827
- DTXCID1028445
- Minolip
- JP 992
- Benfluorexum
- Benfluorexum [INN-Latin]
- SMR000857234
- EINECS 245-777-9
- SE-780
- BRN 4152887
- UNII-403FO0NQG3
- Benflurorex
- Benfluorex [INN:BAN:DCF]
- Mediaxal (TN)
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