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ALVERINE
SynDRA canonical compound SYN0007901 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | HTR1A |
|---|
| Mechanism of action | muscle relaxant |
|---|
| Indication | diverticular disease | irritable bowel syndrome |
|---|
| Disease area | gastroenterology |
|---|
All known targets
Mechanisms of action (all sources)
- HTR1A ANTAGONIST
- Serotonin 1a (5-HT1a) receptor antagonist
- HNF4A ACTIVATOR
- Hepatocyte nuclear factor 4-alpha activator
- HNF4A AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD1
- OPRM1
- ADRA1A
- ADRA2A
- KCNH2
- DRD3
- CHRM1
- CHRM2
- SLC6A4
- SLC6A3
- SLC6A2
- PDE4A
- PDE3A
- MBNL1
- PIN1
- MAOA
- LMNA
- PGR
- ACHE
- PLIN1
- PTGS1
- KDM4E
- SAMHD1
- SLCO1B1
- SLCO1B3
- SMPD1
- TBXA2R
- KDR
- HTR2B
- KDM4A
- IDH1
- ALOX15B
- AR
- BAZ2B
- CYP1A2
- CYP2C19
- CYP2C9
- CYP2D6
- CYP3A4
- EHMT2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- ACM4
- ACM5
- CFTR
- CP1A2
- CP2CJ
- CP2D6
- CP3A7
- DRD2
- GNAI1
- HTR1E
- JUN
- MDR1
- PLIN5
- RGS12
Drug classes
- Parasympatholytics
- Peripheral Nervous System Agents
- muscle relaxant
ATC classes
- A03A · DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Cross-references
Synonyms
- alverine hydrochloride
- dipropylin
- dipropyline
- phenopropamine
- phenpropamine
- alverine citrate
- alverine citrate salt
- Alverina
- Phenpropamine
- Phenopropamine
- Profenil
- Dipropylin
- Dipropyline
- Sestron
- Di(phenylpropyl)ethylamine
- N-Ethyl-3,3'-diphenyldipropylamine
- Sestron base
- Bis(gamma-phenylpropyl)ethylamine
- ethylbis(3-phenylpropyl)amine
- Alverinum
- N,N-Bis(3-phenylpropyl)ethylamine
- N-Ethyl-N-(3-phenylpropyl)benzenepropanamine
- Dipropylamine, N-ethyl-3,3'-diphenyl-
- N-Ethyl-3-phenyl-N-(3-phenylpropyl)-1-propanamine
- CHEBI:518413
- RefChem:111762
- DTXCID0028115
- A03AX08
- Benzenepropanamine, N-ethyl-N-(3-phenylpropyl)-
- N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine
- Alverinum [INN-Latin]
- Alverina [INN-Spanish]
- N-Ethyl-bis(3-phenylpropyl)amin
- Alverine (INN)
- ALVERINE [INN]
- Alverine [INN:BAN]
- HSDB 3284
- EINECS 205-763-5
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