← SynDRA
TRIHEXYPHENIDYL
SynDRA canonical compound SYN0007899 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CHRM1 |
|---|
| Mechanism of action | Acetylcholine receptor antagonist |
|---|
| Indication | parkinsonism |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- CHRM1
- ADRB3
- CHRM2
- CHRM3
- CHRM4
- CHRM5
- CYP2D6
- SIGMAR1
Mechanisms of action (all sources)
- Acetylcholine receptor antagonist
- CHRM1 ANTAGONIST
- Muscarinic acetylcholine receptor M1 antagonist
- ADRB3 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NPY2R
- KCNH2
- DRD2
- ACHE
- MAPT
- OPRD1
- NR3C1
- NPY1R
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- OPRM1
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- IDH1
- HTR6
- HTR2C
- HTR2B
- HTR2A
- OPRK1
- PDE3A
- HRH3
- PDE4A
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMPD1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM4
- ACM5
- CP2D6
- CP3A7
- GLI3
- KCMA1
- MDR1
Drug classes
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Muscarinic Antagonists
- Neurotransmitter Agents
ATC classes
- N04A · ANTICHOLINERGIC AGENTS
Cross-references
Synonyms
- ARTANE
- TREMIN
- TRIHEXYPHENIDYL HYDROCHLORIDE
- trihexyphenidyl hydrochloride
- benzhexol
- benzhexol hydrochloride
- trihexyphenidyl HCl
- benzhexol HCl
- Trihexyphenidyle
- Trihexifenidilo
- Apo-trihex
- NSC-12268
- Benzhexol
- Triphenidyl
- Parkinane retard
- Benzhexolum
- Trihexyphenidylum
- Sedrena (free base)
- Trihexyphenidyle [INN-French]
- Trihexifenidilo [INN-Spanish]
- Trihexyphenidylum [INN-Latin]
- Artane
- Trihexylphenizyl
- Trihexylphenidyl
- Trihexylphenidyle
- Trihexyphenidyl [INN:BAN]
- Trihexylphenedyl
- HSDB 3196
- EINECS 205-614-4
- NSC 12268
- 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-
- BRN 0088959
- Trihexane
- Trihexy
- Artane Sequels
- PMS Trihexyphenidyl
- Apo-Trihex
- Artane (TN)
Reported adverse events
- Neuroleptic malignant syndrome
Look up TRIHEXYPHENIDYL in the interactive SynDRA portal →