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SILDENAFIL
SynDRA canonical compound SYN0007825 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PDE5A |
|---|
| Mechanism of action | Phosphodiesterase inhibitor |
|---|
| Indication | erectile dysfunction |
|---|
| Disease area | urology |
|---|
All known targets
- PDE5A
- SLCO1B3
- ABCC5
- PDE6G
- PDE6H
- PDE6C
- Pde1b
- PDE7A
- PDE8A
- PDE9A
- Pde1a
- Pde1c
Mechanisms of action (all sources)
- Phosphodiesterase inhibitor
- PDE5A INHIBITOR
- Phosphodiesterase 5A inhibitor
- ABCC5 INHIBITOR
- SLCO1B3 INHIBITOR
- SLCO2B1 INHIBITOR
- PDE6C INHIBITOR
- SERPING1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CA5B
- CA1
- ADRA1A
- CA6
- HTR7
- HTR2C
- HTR3A
- HTR5A
- HTR6
- ABCB11
- LCK
- HTR2A
- MAOA
- MAPK1
- MAPK14
- MAPK3
- HTR2B
- HTR1A
- MC4R
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GMNN
- GIPR
- GHSR
- GCGR
- GABBR1
- FYN
- FLT1
- ESR2
- ESR1
- MC3R
- MMP1
- MC5R
- MLNR
- VDR
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP2C9
- CP3A4
- CP3A7
- GLI3
- KSYK
- NR1I2
- NSD2
- PRGR
- RARA
- SO1B3
- SO2B1
- SYK
Drug classes
- Phosphodiesterase 5 Inhibitors
- Cardiovascular Agents
- Enzyme Inhibitors
- Phosphodiesterase Inhibitors
- Urological Agents
- Vasodilator Agents
- Phosphodiesterase 5 Inhibitor
ATC classes
Cross-references
Synonyms
- LIQREV
- Liqrev
- REVATIO
- Revatio
- SILDENAFIL CITRATE
- VIAGRA
- VYBRIQUE
- Viagra
- Vybrique
- mysildecard
- sildenafil citrate
- revatio
- Sildenafilo
- HIP-0908
- HIP0908
- UK-92480
- Rhucin
- Sildenafil [INN:BAN]
- UNII-3M7OB98Y7H
- UK-92,480-10
- C22H30N6O4S
- HSDB 7305
- CHEMBL192
- UK 92480-10
- CHEBI:9139
- 3M7OB98Y7H
- BNRNXUUZRGQAQC-UHFFFAOYSA-N
- Patrex
- Aphrodil
- Sildenafil ratiopharm
- Sildenafil teva
- Vizarsin
- Sildenafil actavis
- sildenafilum
- Nipatra
- RefChem:6218
- DTXCID003579
- G04BE03
Reported adverse events
- Dyspepsia
- Flushing
- Headache
- Hypotension
- Myalgia
- Nausea
- Nasal congestion
- Epistaxis
- Dizziness
- Rash
- Back pain
- Rhinitis
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