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LOSARTAN
SynDRA canonical compound SYN0007815 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | AGTR1 |
|---|
| Mechanism of action | Angiotensin receptor antagonist |
|---|
| Indication | diabetic nephropathy | hypertension |
|---|
| Disease area | cardiology | nephrology |
|---|
All known targets
- AGTR1
- ABCB1
- GP6
- PDE4D
- PDE4C
- PDE4B
- PDE4A
- PDE3B
- PDE3A
- CYP2C9
- ABCG2
- Agtr2
Mechanisms of action (all sources)
- Angiotensin receptor antagonist
- AGTR1 ANTAGONIST
- Type-1 angiotensin II receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- HTR2C
- PPARG
- SLCO1B1
- SLCO1B3
- CNR1
- HTR1D
- HRH3
- MC3R
- MC4R
- MC5R
- MLNR
- MME
- MMP1
- MMP9
- HTR1E
- MPG
- MUTYH
- NEIL1
- NPY1R
- NPY2R
- NR3C1
- MBD4
- MAPK3
- MAPK14
- MAPK1
- NTHL1
- LCK
- KCNH2
- KAT2A
- HTR7
- HTR6
- HRH4
- HTR1A
- HTR5A
- HTR3A
- HTR1B
- HTR2B
- HTR2A
- MAOA
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CFTR
- CP2C9
- CP3A4
- CP3A7
- GLI3
- NUDT15
Drug classes
- Angiotensin 2 Receptor Antagonists
- Angiotensin 2 Receptor Blocker
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin Receptor Antagonists
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Cardiovascular Agents
ATC classes
- C09C · ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
- ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Cross-references
Synonyms
- ARBLI
- Arbli
- COZAAR
- Cozaar
- HYZAAR
- LOSARTAN POTASSIUM
- LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE
- allisartan
- lortaan
- losartan potassium
- losartan monopotassium
- losartan monopotassium salt
- Allisartan
- Angizaar
- Dup-89
- Exp-3174
- Losartan carboxylic acid
- Losartic
- Lozap
- E-3174
- EXP3174
- HGP-1405
- HGP1405
- NSC-758699
- EXP 3174
- UNII-GD76OCH73X
- CHEBI:74125
- CHEMBL907
- GD76OCH73X
- L-158641
- Carboxylic Acid Metabolite (E-3174)
- Cozaar (TN)
- DUP 89
- DuP-753
- Hyzaar
- JMS50MPO89
- Lortaan
- Losartan (INN)
Reported adverse events
- Cough
- Angioedema
- Hepatitis
- Hypotension
- Vasculitis
- Hypersensitivity
- Dysgeusia
- Rhabdomyolysis
- Thrombocytopenia
- Anaphylactic reaction
- Malaise
- Abdominal pain
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