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CAPSAZEPINE
SynDRA canonical compound SYN0007814 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | TRPV1 |
|---|
| Mechanism of action | TRPV agonist |
|---|
All known targets
Mechanisms of action (all sources)
- TRPV agonist
- TRPV1 ANTAGONIST
- TRPV4 INHIBITOR
- TRPV1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ALDH1A1
- NTHL1
- LMNA
- MAPK1
- MAPT
- MBD4
- MPG
- MPHOSPH8
- MUTYH
- NEIL1
- NEIL2
- NFKB1
- NPSR1
- OGG1
- KDM4E
- POLB
- RGS4
- SMUG1
- TARDBP
- TDG
- TDP1
- THPO
- TRPA1
- TRPM8
- TSHR
- UNG
- L3MBTL1
- KDM4A
- ALOX12
- CYP2C9
- ALOX15
- ALOX15B
- APEX1
- ARSA
- ATAD5
- ATXN2
- BAZ2B
- BLM
- CBX1
- CYP1A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ALR
- COMT
- RPGF4
- RAPGEF4
- PNMT
- PHGDH
- PA1B2
- NTM1A
- NNMT
- MDR1
- LOX12
- IL1B
- IDHC
- HS90B
- HS90A
- HNMT
- GNMT
- GLSK
- GEMI
- GAMT
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- STK33
Cross-references
Synonyms
- capsazepin
- N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
- UNII-LFW48MY844
- N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide
- CHEMBL391997
- LFW48MY844
- ST50826300
- CHEBI:70773
- N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide
- N-(2-[4-chlorophenyl]ethyl)-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
- RefChem:123319
- DTXCID4083343
- MFCD00153778
- SR-01000075437
- capasazepine
- Capasazepine?
- Tocris-0464
- Lopac-C-191
- Lopac0_000373
- BSPBio_001550
- KBioGR_000270
- KBioSS_000270
- MLS002153524
- SCHEMBL122421
- GTPL2461
- orb1300007
- SCHEMBL27716486
- SCHEMBL29570456
- BDBM20284
- EX-A7842E
- KBio2_000270
- KBio2_002838
- KBio2_005406
- KBio3_000539
- KBio3_000540
- DRCMAZOSEIMCHM-UHFFFAOYSA-N
- Bio1_000394
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