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L-MIMOSINE
SynDRA canonical compound SYN0007801 — structure-anchored drug synonym record
Clinical phase
Preclinical
Primary target(s)
DBH | EIF5A
Mechanism of action
dopamine beta hydroxylase inhibitor | eukaryotic translation initiation factor inhibitor
All known targets
SHMT1
TYR
CCL2
DBH
DOHH
EIF5A
Malaria SHMT
PPO2
SHMT2
Mechanisms of action (all sources)
dopamine beta hydroxylase inhibitor
eukaryotic translation initiation factor inhibitor
DNA replication inhibitor
Malaria SHMT INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
ACHE
FLT1
NFE2L2
MMP9
MMP1
MLNR
MC5R
MC4R
MC3R
MAPK3
MAPK14
MAPK1
MAOA
LCK
KCNH2
HTR6
HTR3A
HTR2C
HTR2B
HTR2A
HTR1A
HRH2
HRH1
HMGCR
GHSR
NPY1R
NPY2R
NR1I2
PTGS2
TBXAS1
TBXA2R
TACR2
TACR1
SLC6A4
SLC6A3
SLC6A2
SLC29A1
SIGMAR1
PTPRC
PTGS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
CD47
SIRPA
Cross-references
PubChem CID:
3862
ChEMBL:
CHEMBL251433
DrugBank:
DB01055
ChEBI:
CHEBI:29063
KEGG:
C04771
PDB:
MMS
Wikipedia:
Mimosine
TTD: D04ZWL
Synonyms
mimosine
leucaenine
leucaenol
leucenine
leucenol
mimosin
Mimosine
Leucenol
WZNJWVWKTVETCG-UHFFFAOYSA-N
NSC69188
NSC159548
1(4H)-Pyridinealanine, 3-hydroxy-4-oxo-
beta-[N-(3-Hydroxy-4-pyridone)]-alpha-aminopropionic Acid
1(4H)-Pyridinepropanoic acid, .alpha.-amino-3-hydroxy-4-oxo-, (.alpha.S)-
beta-(N-(3-Hydroxy-4-pyridone))-alpha-aminopropionic acid
Prestwick_830
Spectrum_000287
AC1L1GVQ
Spectrum4_000110
Prestwick0_000379
Mimosine, (+/-)-
Spectrum2_000656
Spectrum3_000722
Prestwick2_000379
Spectrum5_001484
Prestwick1_000379
Leucenine
Leucaenine
Leucaenol
Mimosin
(L)-MIMOSINE
Z46B1LUI5N
(2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1-yl)propanoic acid
(S)-alpha-Amino-3-hydroxy-4-oxo-1(4H)-pyridylpropionic acid
CHEBI:29063
NSC-69188
(S)-2-Amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate
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