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NICARDIPINE
SynDRA canonical compound SYN0007800 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CACNA1C |
|---|
| Mechanism of action | Calcium channel blocker |
|---|
| Indication | chronic stable angina | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- CACNA1C
- ADORA3
- CACNA1D
- CACNA1S
- CACNA1F
- KCND2
- Cacna1c
- Cacna1d
- Cacna1s
- ABCB1
- CYP3A4
- Kcna4
Mechanisms of action (all sources)
- Calcium channel blocker
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- ADORA3 ANTAGONIST
- potassium channel blocker
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- ESR1
- DRD1
- CYP2J2
- CYP2D6
- CYP2C8
- CYP2C19
- HTR1A
- CHRM2
- CHRM1
- KCNH2
- SLC6A3
- TBXA2R
- SLC6A2
- PGR
- PDE4A
- SCN5A
- OPRM1
- MTOR
- DRD3
- POLI
- POLK
- RAB9A
- PMP22
- PIN1
- PDE3A
- PTGS1
- SLCO1B1
- SAMHD1
- SLC6A4
- NPC1
- SLCO1B3
- SLCO2B1
- SMN1
- TDP1
- THPO
- TP53
- TRPV1
- TSHR
- USP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- PRKN
- KCMB4
- KSYK
- MDR1
- NR1H4
- NSD2
- PRGR
- RARA
- ACM4
- RXFP1
- SMAD2
- SMAD3
- STK33
- SYK
- TAAR1
- KCMB2
- IL1B
- HSPB1
- GLI3
- GCR
- ESRRA
- ESR2
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP19A
- CAC1H
- BAZ2B
- ARRB1
- ANDR
- TMIG3
Drug classes
- Calcium Channel Antagonists
- Dihydropyridine Calcium Channel Blocker
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
- Cytochrome P450 2D6 Inhibitors
- Cytochrome P450 2C19 Inhibitors
- Cytochrome P450 3A4 Inhibitors
- Cytochrome P450 2C8 Inhibitors
ATC classes
- C08C · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Cross-references
Synonyms
- CARDENE
- CARDENE IN 0.83% SODIUM CHLORIDE IN PLASTIC CONTAINER
- CARDENE IN 0.86% SODIUM CHLORIDE IN PLASTIC CONTAINER
- CARDENE IN 4.8% DEXTROSE IN PLASTIC CONTAINER
- CARDENE IN 5.0% DEXTROSE IN PLASTIC CONTAINER
- CARDENE SR
- Cardene
- NICARDIPINE HYDROCHLORIDE
- NICARDIPINE HYDROCHLORIDE IN 0.83% SODIUM CHLORIDE
- NICARDIPINE HYDROCHLORIDE IN 0.86% SODIUM CHLORIDE
- NICARDIPINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE
- (+/-)-Nicardipine
- perpidine
- nicardipine hydrochloride
- nicardipine HCl
- Nicardipino
- Nicardipine (stn)
- Perpidine
- Nicardipinum
- Cardene IV
- Nicardipine LA
- Cardene (TN)
- Nicardipine (INN)
- Nicardipine [INN:BAN]
- Nicardipino [INN-Spanish]
- Nicardipinum [INN-Latin]
- Y-93
- CZ5312222S
- (+-)-nicardipine
- CHEBI:7550
- DTXCID903363
- nicardipina
- LA, Nicardipine
- RefChem:56587
- Hydrochloride, Nicardipine
- C08CA04
- YC-93 (free base)
- MFCD00216027
Reported adverse events
- Asthenia
- Constipation
- Dizziness
- Dyspepsia
- Flushing
- Headache
- Insomnia
- Malaise
- Myalgia
- Nausea
- Nervousness
- Nocturia
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