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FELODIPINE
SynDRA canonical compound SYN0007705 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CACNA1S |
|---|
| Mechanism of action | Calcium channel blocker |
|---|
| Indication | angina pectoris | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- CACNA1C
- CACNA1D
- CACNA1S
- CFTR
- NR3C2
- CACNA1F
- ADORA3
- AOX1
- CACNA1H
- CYP2C9
- NR1H4
- SCN1A
Mechanisms of action (all sources)
- Calcium channel blocker
- NR3C2 ANTAGONIST
- Mineralocorticoid receptor antagonist
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- CFTR POTENTIATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SCN5A
- ESR1
- OPRK1
- PDE4D
- PGR
- NR1I2
- NR3C1
- TBXA2R
- HTR2A
- MC3R
- NPY2R
- NPY1R
- HRH1
- NPSR1
- MTOR
- HRH2
- MPHOSPH8
- HRH3
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MAPT
- HTR2B
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDM4E
- KCNH2
- HTR6
- HTR3A
- HTR1A
- HTR2C
- ABCB1
- OPRD1
- NTSR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AHR
- KCMB2
- TF65
- RPGF4
- RPGF3
- RARA
- RAPGEF4
- RAPGEF3
- PRKN
- PRGR
- PE2R2
- NTM1A
- NFKB1
- NF2L2
- KCNQ1
- KCMB4
- IFNB1
- ANDR
- HLAB
- GPR55
- GPR32
- GEMI
- GCR
- ESRRA
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- BAP1
- AURKB
- TYRP1
Drug classes
- Calcium Channel Antagonists
- Dihydropyridine Calcium Channel Blocker
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
ATC classes
- C08C · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
- BETA BLOCKING AGENTS, OTHER COMBINATIONS
- ACE INHIBITORS, COMBINATIONS
Cross-references
Synonyms
- LEXXEL
- PLENDIL
- (RS)-Felodipine
- (+/-)-Felodipine
- flodil
- dl-Felodipine
- Felodipino
- C08CA02
- H-154/82
- NSC-760343
- Cabren
- Cardioplen xl
- Felodipine component of lexxel
- Felogen xl
- Felotens xl
- Folpik xl
- Keloc sr
- Neofel xl
- Parmid xl
- Pinefeld xl
- Plendil
- Preslow
- Vascalpha
- Agon
- Felobeta
- Felocor
- Feloday
- Felodipina
- Felodipinum
- Felodur
- Felogamma
- Felogard
- Fensel
- Flodil
- Hydac
- Lexxel
- Logimax
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