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LITHOCHOLIC ACID
SynDRA canonical compound SYN0007695 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | GPBAR1 | MDM2 | MDM4 | NR1H4 | NR1I2 | PTPN1 | VDR |
|---|
| Mechanism of action | FXR antagonist | vitamin D receptor agonist |
|---|
All known targets
- NR1H4
- ERBB2
- GPBAR1
- MDM2
- MDM4
- NR1I2
- PTPN1
- VDR
- VEGFA
Mechanisms of action (all sources)
- NR1H4 ANTAGONIST
- vitamin D receptor agonist
- VEGFA INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PTPN2
- ABCC4
- MBD4
- S1PR1
- RXRA
- RORC
- RAPGEF3
- PPARG
- PPARD
- POLK
- POLI
- PLK1
- OGG1
- NR3C1
- NFKB1
- NFE2L2
- NEIL2
- NEIL1
- NAPEPLD
- SAMHD1
- SLC10A1
- SLCO1B1
- TRIM24
- UGT2B4
- UGT2B17
- UGT2B15
- UGT1A8
- UGT1A10
- TST
- TSHR
- TP53
- SLCO1B3
- THRB
- TDP1
- TDG
- ST6GAL1
- ST3GAL1
- SNCA
- SMUG1
- MPG
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- CASP3
- SENP8
- RARA
- PRGR
- NF2L2
- MK01
- MDR1
- JUN
- HSPE1
- HSPD1
- HSPB1
- GPBAR
- GNRHR
- GCR
- ESRRA
- ESR2
- CTDS1
- CP2D6
- TRHR
Drug classes
Cross-references
Synonyms
- Bevacizumab + Trastuzumab
- Lithocolic acid
- Lithocholate
- 3alpha-Hydroxy-5beta-cholanic acid
- 3alpha-Hydroxy-5beta-cholan-24-oic acid
- 3-Hydroxycholan-24-oic acid
- 3alpha-Hydroxycholanic acid
- 3-alpha-Hydroxycholanic acid
- 5beta-Cholanic acid-3alpha-ol
- NCI-C03861
- 3alpha-Hydroxy-5beta-cholanoic acid
- (3alpha,5beta)-3-hydroxycholan-24-oic acid
- 3-alpha-Hydroxy-5-beta-cholanic acid
- CCRIS 363
- UNII-5QU0I8393U
- 3alpha-Hydroxy-5beta-cholanate
- 5-beta-Cholanic acid, 3-alpha-hydroxy-
- Cholan-24-oic acid, 3-hydroxy-,
- BRD-K20986251
- lithocholic-acid
- 5beta-Cholan-24-oic acid, 3alpha-hydroxy-
- Cholan-24-oic acid, 3-hydroxy-, (3alpha,5beta)-
- 5QU0I8393U
- 5-beta-Cholan-24-oic acid, 3-alpha-hydroxy-
- NSC 683770
- DTXCID80779
- CHEBI:16325
- Cholan-24-oic acid, 3-hydroxy-, (3-alpha,5-beta)-
- NSC 657956
- Acid, Isolithocholic
- Acid, Lithocholic
- RefChem:153789
- MFCD00003682
- NSC683770
- (3-alpha,5-beta)-3-Hydroxycholan-24-oic acid
- 3.alpha.-Hydroxycholanic acid
- 3|A-Hydroxy-5|A-cholanic acid
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