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APREPITANT
SynDRA canonical compound SYN0007629 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TACR1 |
|---|
| Mechanism of action | Tachykinin antagonist |
|---|
| Indication | nausea | vomiting |
|---|
| Disease area | gastroenterology |
|---|
All known targets
- TACR1
- CYP2C19
- CYP3A4
- TACR3
Mechanisms of action (all sources)
- Tachykinin antagonist
- TACR1 ANTAGONIST
- Neurokinin 1 receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- GPR65
- GPR35
- GPR183
- ESR1
- MC3R
- NPY1R
- NEIL2
- NEIL1
- MLNR
- MC4R
- ADGRF1
- MAOA
- HRH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- NR1I2
- NR3C1
- NTHL1
- OGG1
- TDG
- TBXA2R
- SMUG1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- S1PR1
- PTGS2
- PGR
- PDE4D
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- HTR1A
- HDAC6
- HRH1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CASP3
- CASP7
- CP19A
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- ESRRA
- GLI3
- NSD2
- PPARD
- RARA
- RXFP1
- TP53
Drug classes
- Neurokinin 1 Antagonists
- Antiemetics
- Central Nervous System Agents
- Gastrointestinal Agents
- Neurokinin-1 Receptor Antagonists
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Substance P/Neurokinin-1 Receptor Antagonist
- Cytochrome P450 3A4 Inhibitors
- Cytochrome P450 3A4 Inducers
- Cytochrome P450 2C9 Inducers
ATC classes
- A04A · ANTIEMETICS AND ANTINAUSEANTS
Cross-references
Synonyms
- APONVIE
- Aponvie
- CINVANTI
- Cinvanti
- EMEND
- Emend
- emend
- L-754030
- ONO-7436
- APREPITANT (MK-0869)
- APREPITANT`
- L-754,030
- MK-0869
- MK-869
- NSC-748825
- Aprepitant [USAN]
- Emend (TN)
- Aprepitant (JAN/USAN/INN)
- MK-869, L-754030, Emend, Aprepitant
- NSC 748825
- MK 869
- L 754,030
- aprepitant (usp monograph)
- aprepitant (ep monograph)
- aprepitant (usp-rs)
- ONO 7436
- MK 0869
- 1NF15YR6UY
- L 754030
- aprepitantum
- CHEBI:499361
- DTXCID801021794
- RefChem:57104
- A04AD12
- MK869
- MK0517
- L754030
Reported adverse events
- Infection
- Stevens-Johnson syndrome
- Angioedema
- Asthenia
- Bradycardia
- Constipation
- Dizziness
- Fatigue
- Headache
- Hiccups
- Tinnitus
- Infestation
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