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TIPIRACIL
SynDRA canonical compound SYN0007626 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TYMP |
|---|
| Mechanism of action | Thymidine phosphorylase inhibitor |
|---|
| Indication | colorectal cancer |
|---|
| Disease area | oncology |
|---|
All known targets
Mechanisms of action (all sources)
- Thymidine phosphorylase inhibitor
- TYMP INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- ADORA3
- SLC6A4
- SLC6A3
- SLC6A2
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KDR
- KCNH2
- HTR2B
- HTR1A
- HRH3
- HDAC6
- F2
- ESR1
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- TBXA2R
Drug classes
- Thymidine Phosphorylase Inhibitors
- Thymidine Phosphorylase Inhibitor
Cross-references
Synonyms
- LONSURF
- TIPIRACIL HYDROCHLORIDE AND TRIFLURIDINE
- tipiracil hydrochloride
- tipiracil HCl
- Tipiracilo
- MA-1
- TPI (freebase)
- NGO10K751P
- 5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL) METHYL) URACIL
- TPI
- Tipiracil [INN]
- Tipiracil [USAN:INN]
- 5-CIMU
- UNII-NGO10K751P
- TIPIRACIL [MI]
- TIPIRACIL [USAN]
- TIPIRACIL [WHO-DD]
- CHEMBL235668
- GTPL8696
- SCHEMBL1682960
- BDBM20079
- CHEBI:90879
- HY-A0063A
- DTXSID601025833
- HMS3745A05
- BCP24231
- BDBM50531739
- ZINC100032379
- CS-5895
- DB02631
- DB09343
- NCGC00389632-02
- NCGC00389632-07
- DB-065427
- FT-0758894
- A927069
- EN300-23231135
- Q21098889
Reported adverse events
- Abdominal pain
- Alopecia
- Constipation
- Dysgeusia
- Fatigue
- Headache
- Hypertension
- Infection
- Nausea
- Neutropenia
- Proteinuria
- Pyrexia
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