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PHENYLBUTANOIC ACID
SynDRA canonical compound SYN0007602 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A5 | HDAC1 |
|---|
| Mechanism of action | HDAC inhibitor |
|---|
| Indication | urea cycle disorders |
|---|
| Disease area | metabolism |
|---|
All known targets
- HDAC1
- AKR1B1
- CYP3A5
- HDAC2
- HDAC8
- PRKCA
Mechanisms of action (all sources)
- histone deacetylase inhibitor
- HDAC1 INHIBITOR
- PRKCA MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HDAC6
- DRD1
- SLC6A3
- HTR7
- NPY1R
- MLNR
- MC4R
- MC3R
- MAPK1
- MAOA
- KCNH2
- ABCB11
- NPY2R
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HTR6
- NTSR1
- NR3C1
- SLC6A2
- TAS2R39
- TACR2
- TACR1
- SMN1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC29A1
- OPRD1
- SIRT5
- PTGS2
- PGR
- PDE4D
- PDE3A
- OPRM1
- OPRK1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- HDAC10
- HDAC11
- HDAC3
- HDAC4
- HDAC5
- HDAC7
- HDAC9
Drug classes
ATC classes
- A16A · OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Cross-references
Synonyms
- BUPHENYL
- Buphenyl
- OLPRUVA
- Olpruva
- PHEBURANE
- Pheburane
- RELYVRIO
- Relyvrio
- SODIUM PHENYLBUTYRATE
- phenylbutyrate
- sodium 4-phenylbutanoate
- sodium 4-phenylbutyrate
- buphenyl
- pheburane
- benzenebutyric acid
- 4-Phenylbutanoic acid
- 4-Phenylbutyric acid
- gamma-Phenylbutanoic acid
- sodium phenylbutyrate
- relyvrio
- Phenylbutyrate
- Benzenebutyric acid
- Phenyl butanoate
- Phenyl butyrate
- HDInhib_000004
- Butanoic acid, phenyl ester
- Butyric acid, phenyl ester
- FR-2080
- Gamma-Phenylbutyric acid
- Omega-Phenylbutanoic acid
- GAMMA-PHENYL-BUTYRIC ACID
- Butyric acid, 4-phenyl-(8CI)
- 1-Phenylbutyric acid
- 4-PHENYL-BUTANOIC ACID
- 4-PHENYLBUTYRIC ACID
- 4-phenylbutans
- 4-phenylbutyrate
- Sodium phenylbutyrate
Reported adverse events
- Neurotoxicity
- Decreased appetite
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