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RIFABUTIN
SynDRA canonical compound SYN0007594 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | protein synthesis inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP3A4
- rpoA
- rpoB
- rpoC
- rpoZ
Mechanisms of action (all sources)
- protein synthesis inhibitor
- rpoA INHIBITOR
- rpoZ INHIBITOR
- rpoC INHIBITOR
- rpoB INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- KCNH2
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- HTR6
- NPY1R
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- FYN
- FLT1
- MMP9
- NPY2R
- ABCC2
- PTGS2
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
- SIGMAR1
- PTPRC
- PTGS1
- NR3C1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- KCMA1
- KCMB1
- KCMB2
- MAPT
- NR1I2
- VDR
Drug classes
- Rifamycin Antimycobacterial
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibiotics, Antitubercular
- Antitubercular Agents
ATC classes
- J04A · DRUGS FOR TREATMENT OF TUBERCULOSIS
- DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Cross-references
Synonyms
- MYCOBUTIN
- Mycobutin
- TALICIA
- ansamycin
- mycobutin
- rifabutine
- Rifabutine
- Rifabutina
- Ansamycin
- LM-427
- Rifabutin component of talicia
- Alfacid
- Ansatipin
- Ansatipine
- Assatipin
- RBT
- Rifabutinum
- Grunenthal Brand of Rifabutin
- Kenfarma Brand of Rifabutin
- Pfizer Brand of Rifabutin
- Rifabutin Pfizer Brand
- Rifabutina [Spanish]
- Rifabutine [French]
- Rifabutinum [Latin]
- Antibiotic LM 427
- LM427
- DRG-0085
- Mycobutin (TN)
- Rifabutin [USAN:BAN:INN]
- Rifabutin (JAN/USP/INN)
- Mycobutin, Ansamycin, LM 427, Ansatipine, Rifabutin
- 4-N-isobutylspiropiperidylrifamycin S
- 4-N-Isobutylspiropiperidylrifamycin S
- Ansamicin
- Mycobutin (tn)
- الريفابوتين
- 72559-06-9
Reported adverse events
- Dyspepsia
- Flatulence
- Headache
- Nausea
- Rash
- Uveitis
- Vomiting
- Abdominal pain
- Asthenia
- Corneal deposits
- Eosinophilia
- Eructation
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