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PRETOMANID
SynDRA canonical compound SYN0007067 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | FASN |
|---|
| Mechanism of action | nitric oxide donor |
|---|
All known targets
- FASN
- MycB cmaA1
- MycB cmaA2
- MycB pcaA
Mechanisms of action (all sources)
- nitric oxide donor
- MycB cmaA1; MycB cmaA2; MycB pcaA INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- NPY1R
- HRH2
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- HTR6
- HTR7
- KCNH2
- MAOA
- MC3R
- MC4R
- MLNR
- NPY2R
- HMBS
- NTSR1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4A
- PDE4D
- PGR
- PTGS1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TACR1
- HRH1
- HDAC6
- ADORA1
- BDKRB2
- ADORA2A
- ADORA3
- ADRA1A
- ADRA2A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antimycobacterial
- Organic Anion Transporter 3 Inhibitors
ATC classes
- J04A · DRUGS FOR TREATMENT OF TUBERCULOSIS
Cross-references
Synonyms
- PA-824
- PA824
- Dovprela (previously pretomanid fgk)
- PA 824
- UNII-2XOI31YC4N
- (S)-PA 824
- 2XOI31YC4N
- CHEMBL227875
- MMV688755
- AK161427
- Pretomanid [USAN:INN]
- C14H12F3N3O5
- PA-824(Pretomanid)
- AC1L9UFX
- Pretomanid (USAN/INN)
- MLS006011141
- SCHEMBL2983011
- PA824 cpd
- pretomanidum
- RefChem:57158
- DTXCID6021163
- MFCD06809939
- (S)-PA 824 (Pretomanid)
- Pretomanid (Standard)
- PRETOMANID [MI]
- PRETOMANID [INN]
- PA-824(Pretomanid)?
- PRETOMANID [USAN]
- Pretomanid(S)-PA 824
- PRETOMANID [WHO-DD]
- orb1301077
- orb3141401
- PRETOMANID [ORANGE BOOK]
- GTPL11172
- ZLHZLMOSPGACSZ-NSHDSACASA-N
- GLXC-02683
- EX-A1749
Reported adverse events
- Abdominal pain
- Abnormal loss of weight
- Acne
- Constipation
- Cough
- Dry skin
- Dyspepsia
- Gamma-glutamyltransferase increased
- Gastritis
- Headache
- Hepatotoxicity
- Hypertension
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