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EFAVIRENZ
SynDRA canonical compound SYN0006825 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | HIV protease inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP3A4
- CYP2B6
- CYP2C19
- CYP2C9
- CYP2D6
- CYP1A2
- ABCG2
- env
- reverse transcriptas
- pol
- gag-pol
- CYP3A5
Mechanisms of action (all sources)
- protease inhibitor
- HIV RT MODULATOR
- pol INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2A
- HTR2C
- NR3C1
- ADORA3
- ESR1
- OPRK1
- DRD2
- MC4R
- OPRD1
- NPY1R
- NPSR1
- MLNR
- ABCB1
- MC3R
- MAPK1
- MAOA
- KCNH2
- HTR3A
- MAPT
- OPRM1
- PDE3A
- PDE4D
- PGR
- PPARG
- PTGS2
- SAMHD1
- SLC22A1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- SLCO2B1
- TBXA2R
- HTR2B
- HRH3
- HTR1A
- ABCC1
- ABCC2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- NNMT
- KCMA1
- KCMB1
- KCMB2
- KCMB4
- KSYK
- NF2L2
- NSD2
- ANDR
- PNMT
- PRGR
- RAPGEF4
- RARA
- RPGF4
- SYK
- JUN
- HSPB1
- HNMT
- GNMT
- GCR
- GAMT
- ESRRA
- ESR2
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- CP19A
- COMT
- CAC1H
- TSHR
Drug classes
- Non-Nucleoside Reverse Transcriptase Inhibitors
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Anti-Infective Agents
- Antiviral Agents
- Cytochrome P-450 CYP2B6 Inducers
- Cytochrome P-450 CYP2C19 Inhibitors
- Cytochrome P-450 CYP2C9 Inhibitors
- Cytochrome P-450 CYP3A Inducers
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Metabolic Side Effects of Drugs and Substances
- Nucleic Acid Synthesis Inhibitors
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- ATRIPLA
- EFAVIRENZ, EMTRICITABINE, AND TENOFOVIR DISOPROXIL FUMARATE
- EFAVIRENZ, LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE
- EFAVIRENZ; EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE
- EFAVIRENZ; EMTRICITABINE; TENOFOVIR DISOPROXIL FUMARATE
- SUSTIVA
- SYMFI
- SYMFI LO
- stocrin
- (-)-efavirenz
- sustiva
- Efavirenz teva
- Efavirenzum
- Stocrin
- Viraday
- DMP-266
- L-743726
- NSC-742403
- Efavirenz component of atripla
- Efavirenz component of symfi
- Efavirenz component of telura
- Sustiva
- Sustiva 600
- EFV
- EFZ
- Eravirenz
- L-741211
- L-743725
- Stocrin (TN)
- Strocin (TM)
- Sustiva (TM)
- Sustiva (TN)
- Efavirenz (JAN/INN)
- L-743,726
- Zoxazin-2-one
- Efavirenz, (S)-isomer
- (-)-Efavirenz
Reported adverse events
- Lactic acidosis
- Rash
- Stevens-Johnson syndrome
- Fanconi syndrome
- Anxiety
- Depression
- Dizziness
- Headache
- Hepatotoxicity
- Insomnia
- Nausea
- Pancreatitis
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