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NAFCILLIN
SynDRA canonical compound SYN0006809 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC22A6 |
|---|
| Mechanism of action | Bacterial cell wall synthesis inhibitor |
|---|
| Indication | gram-positive bacterial infections |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP1A2
- CYP3A4
- SLC22A6
- PBP2
- mecA
- pbp4
- pbpA
- pbpF
Mechanisms of action (all sources)
- Bacterial cell wall synthesis inhibitor
- pbp4 INHIBITOR
- mecA INHIBITOR
- pbpA INHIBITOR
- PBP2 INHIBITOR
- pbpF INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD3
- ABCB11
- HTR2B
- KCNH2
- KDM4A
- KDR
- LMNA
- MAOA
- OPRM1
- PDE3A
- PDE4A
- PGR
- PTGS1
- SAMHD1
- SLC22A8
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- TBXA2R
- KAT2A
- HTR1A
- ACHE
- CYP2D6
- ADORA3
- ADRA1A
- ADRA2A
- AR
- CHRM1
- CHRM2
- CYP2C19
- CYP2C9
- DRD1
- HRH3
- EHMT2
- ESR1
- F2
- GLP1R
- GLS
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Penicillin-class Antibacterial
- Anti-Bacterial Agents
- Anti-Infective Agents
ATC classes
- J01C · BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Cross-references
Synonyms
- NAFCILLIN SODIUM
- NALLPEN
- NALLPEN IN PLASTIC CONTAINER
- UNIPEN
- UNIPEN IN PLASTIC CONTAINER
- naphthamidopenicillin
- nafcilin
- nallpen
- naphcillin
- nafcillin sodium
- nafcillin sodium salt monohydrate
- nafcillin sodium salt
- Nafcilline
- Nafcilina
- Nafcillinum
- Nallpen
- Naphcillin
- Naphthamidopenicillin
- Unipen
- Nafcillin sodium for injection
- Nallpen In Plastic Container
- Nafcilin-1
- Nafcilina [INN-Spanish]
- Nafcillin & VRC3375
- Nafcillin (INN)
- Nafcillin [INN:BAN]
- Nafcilline [INN-French]
- Nafcillinum [INN-Latin]
- Nafcillin, Monosodium Salt, Anhydrous
- (2-Ethoxy-1-naphthyl)penicillin
- (2-ethoxy-1-naphthalenyl)penicillin
- 6-(2-ethoxy-1-naphthamido)penicillanic acid
- Nafcillin sodium salt
- CHEBI:7447
- Penicillin, (2-ethoxy-1-naphthalenyl)-
- 4CNZ27M7RV
- NAFCILLIN [INN]
- HSDB 3133
Reported adverse events
- Agranulocytosis
- Nausea
- Pseudomembranous colitis
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