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PEMETREXED
SynDRA canonical compound SYN0006801 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TYMS |
|---|
| Mechanism of action | Dihydrofolate reductase inhibitor |
|---|
| Indication | mesothelioma | non-small cell lung cancer (NSCLC) |
|---|
| Disease area | oncology |
|---|
All known targets
- DHFR
- TYMS
- GART
- ATIC
- SLC19A1
- folA
- dfrA17
- Tyms
- SLC46A1
- SLC22A8
- SHMT1
- Candi TMP1
Mechanisms of action (all sources)
- thymidylate synthase inhibitor
- dihydrofolate reductase inhibitor
- TYMS INHIBITOR
- GART INHIBITOR
- GAR transformylase inhibitor
- DHFR INHIBITOR
- Candi TMP1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Folic Acid Metabolism Inhibitors
- Folate Analog Metabolic Inhibitor
- Antineoplastic Agents
- Enzyme Inhibitors
- Folic Acid Antagonists
- Nucleic Acid Synthesis Inhibitors
ATC classes
Cross-references
Synonyms
- ALIMTA
- AXTLE
- Alimta
- Axtle
- PEMETREXED DISODIUM
- PEMETREXED DITROMETHAMINE
- PEMFEXY
- Pemfexy
- Pemrydi Rtu
- LY231514
- pemetrexed diacid monohydrate
- pemetrexed sodium
- pemetrexed sodium hydrate
- pemetrexed disodium
- alimta
- pemetrexed disodium heptahydrate
- LY-231514
- NSC-698037
- LYA
- Alimta (TN)
- LY-231,514
- LY-2315
- Pemetrexed (INN)
- Pemetrexed [INN:BAN]
- LY 231514
- CHEBI:63616
- Pemetrexed Sodium
- pemetrexedum
- Multitargeted Antifolate
- RefChem:6105
- PEMETREXED FOR INJECTION
- DTXCID7028304
- LY 231,514
- PEMETREXED [INN]
- UNII-04Q9AIZ7NO
- MFCD19105065
- s5971
Reported adverse events
- Fatigue
- Nausea
- Rash
- Pyrexia
- Stevens-Johnson syndrome
- Conjunctivitis
- Constipation
- Dyspepsia
- Febrile neutropenia
- Infection
- Neutropenia
- Renal failure
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