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LINIFANIB
SynDRA canonical compound SYN0006689 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Primary target(s) | PDGFRB |
|---|
| Mechanism of action | VEGFR inhibitor |
|---|
All known targets
- FLT4
- CSF1R
- FLT1
- FLT3
- KDR
- PDGFRB
- PDGFRA
- KIT
- RET
- TEK
- CDK19
- CDK8
Mechanisms of action (all sources)
- PDGFR inhibitor
- VEGFR inhibitor
- CSF1R INHIBITOR
- Macrophage colony stimulating factor receptor inhibitor
- FLT3 INHIBITOR
- Tyrosine-protein kinase receptor FLT3 inhibitor
- PDGFRB INHIBITOR
- Platelet-derived growth factor receptor inhibitor
- PDGFRA INHIBITOR
- FLT1 INHIBITOR
- Vascular endothelial growth factor receptor inhibitor
- FLT4 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PRKACA
- SRMS
- EPHB2
- EPHB3
- EPHB4
- STK10
- EPHB6
- CDK9
- CDK7
- DDR1
- DDR2
- ROCK1
- LIMK2
- MAP4K1
- STK26
- STK3
- CDK16
- STK32A
- STK32B
- CDK13
- CDK11B
- CDK11A
- CDK1
- STK33
- CDC42BPG
- SRPK1
- SRC
- LTK
- MAP3K19
- EGFR
- RPS6KA4
- RPS6KA5
- INSRR
- RPS6KB1
- INSR
- IRAK1
- PTK2
- MAP2K5
- SGK3
- EPHA2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CSK21
- KS6A5
- NSD2
- MP2K2
- MK15
- MK14
- MK09
- M4K5
- M4K2
- M3K20
- KSYK
- KS6B1
- KS6A4
- CYP19A1
- KGP1
- KCC2G
- KCC2D
- KCC2B
- KCC1A
- KC1G2
- KC1G1
- KC1D
- ITGAL
- IFNG
- ST32B
Cross-references
Synonyms
- A-741439
- ABT-869
- AL-39324
- RG-3635
- ABT 869
- S1003_Selleck
- ABT869, Linifanib, AL-39324, RG3635
- N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea
- N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea
- Linifanib (ABT-869)
- 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
- AL 39324
- 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
- N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
- ABT869
- RG3635
- CHEMBL223360
- CO93X137CW
- Urea, N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)-
- Linifanib [USAN]
- Kinome_532
- Linifanib [USAN:INN]
- linifanibum
- UNII-CO93X137CW
- Aminoindazole, 3
- ABT-869,Linifanib
- LINIFANIB [INN]
- Linifanib (USAN/INN)
- Linifanib - ABT-869
- LINIFANIB [WHO-DD]
- SCHEMBL93804
- MLS006010276
- GTPL5657
- BDBM21079
- CHEBI:91435
- AMY7508
- DTXSID40229834
- EX-A014
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