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METFORMIN
SynDRA canonical compound SYN0006629 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ACACB | INS | PRKAB1 |
|---|
| Mechanism of action | insulin sensitizer |
|---|
| Indication | diabetes mellitus |
|---|
| Disease area | endocrinology |
|---|
All known targets
- NDUFAF4
- NDUFV1
- NDUFAF2
- NDUFAF3
- COXFA4
- NDUFB1
- NDUFB10
- NDUFB11
- NDUFB2
- NDUFB3
- NDUFB4
- NDUFB5
Mechanisms of action (all sources)
- MT-ND6 INHIBITOR
- Mitochondrial complex I (NADH dehydrogenase) inhibitor
- NDUFA10 INHIBITOR
- NDUFS8 INHIBITOR
- MT-ND4L INHIBITOR
- NDUFA6 INHIBITOR
- MT-ND1 INHIBITOR
- NDUFB6 INHIBITOR
- COXFA4 INHIBITOR
- NDUFA11 INHIBITOR
- NDUFB7 INHIBITOR
- MT-ND2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADRA1A
- ACHE
- MMP1
- MAPK14
- MAPK3
- MC3R
- MC4R
- MC5R
- MLNR
- MMP9
- MAOA
- MTOR
- NPY1R
- NPY2R
- NR3C1
- NTSR1
- MAPK1
- LMNA
- OPRK1
- LCK
- KDR
- KCNH2
- KAT2A
- HTT
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- OPRD1
- OPRM1
- HDAC6
- PDE3A
- TDP1
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Biguanide
- Hypoglycemic Agents
ATC classes
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- ACTOPLUS MET
- ACTOPLUS MET XR
- AVANDAMET
- DAPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE
- EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE
- FORTAMET
- GLIPIZIDE AND METFORMIN HYDROCHLORIDE
- GLUCOPHAGE
- GLUCOPHAGE XR
- GLUCOVANCE
- GLUMETZA
- GLYBURIDE AND METFORMIN HYDROCHLORIDE
- metformin hydrochloride
- glucophage
- LA 6023
- N,N-dimethylguanylguanidine
- metformin HCl
- Metformine
- Metformina
- Metformin extended release
- LA-6023
- 1,1-Dimethylbiguanide
- N,N-dimethylimidodicarbonimidic diamide
- Metiguanide
- Dimethylbiguanide
- Haurymelin
- Gliguanid
- Fluamine
- Flumamine
- Melbin
- Diabex
- N,N-Dimethylbiguanide
- Metforminum
- Islotin
- Glifage
- Siofor
- N1,N1-Dimethylbiguanide
- DMGG
Reported adverse events
- Lactic acidosis
- Lactic acid
- Metformin associated lactic acidosis
- Nausea
- Headache
- Vomiting
- Flatulence
- Asthenia
- Abdominal pain
- Dizziness
- Angioedema
- Hypersensitivity
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