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DORZOLAMIDE
SynDRA canonical compound SYN0006485 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CA2 |
|---|
| Mechanism of action | Carbonic anhydrase inhibitor |
|---|
| Indication | glaucoma | intraocular pressure |
|---|
| Disease area | ophthalmology |
|---|
All known targets
- CA2
- CA1
- CA12
- CA14
- CA4
- CA7
- AR
- CAN2
- mtcA1
- cynT
- ca1
- NCE103
Mechanisms of action (all sources)
- Carbonic anhydrase inhibitor
- CA2 INHIBITOR
- Carbonic anhydrase II inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- KCNH2
- TBXA2R
- SLC6A4
- SLC6A3
- SLC6A2
- SAMHD1
- PTGS1
- POLI
- PGR
- PDE4A
- PDE3A
- OPRM1
- NFE2L2
- MAOA
- KDR
- HTR2B
- ADORA3
- HTR1A
- HRH3
- HDAC6
- GMNN
- F2
- ESR1
- DRD3
- DRD1
- CISD1
- CHRM2
- CHRM1
- CBX1
- ADRA2A
- ADRA1A
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Carbonic Anhydrase Inhibitors
- Carbonic Anhydrase Inhibitor
- Antihypertensive Agents
- Cardiovascular Agents
- Enzyme Inhibitors
ATC classes
- S01E · ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Cross-references
Synonyms
- COSOPT
- COSOPT PF
- DORZOLAMIDE HYDROCHLORIDE
- DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE
- TRUSOPT
- dorzolamide hydrochloride
- dorzolamide HCl
- Dorzolamida
- Dorzolamide, trans-(-)-
- Dorzant
- Trusopt
- Dorzolamide (DZA)
- Dorzolamide (INN)
- Trusopt (TN)
- 4S,6S-Dorzolamide
- 9JDX055TW1
- CHEBI:4702
- DORZOLAMIDE [INN]
- Dorzolamide impurity A
- Dorzolamide [INN:BAN]
- UNII 9JDX055TW1
- SR-05000001449
- 1cil
- DORZOLAMIDE [MI]
- Prestwick0_001116
- Prestwick1_001116
- Prestwick2_001116
- Prestwick3_001116
- DORZOLAMIDE [VANDF]
- SCHEMBL24061
- BSPBio_001252
- DORZOLAMIDE [WHO-DD]
- MLS006011430
- BIDD:GT0306
- SPBio_003116
- BPBio1_001377
- CHEMBL218490
- GTPL6810
Reported adverse events
- Hypersensitivity
- Stevens-Johnson syndrome
- Alopecia
- Arrhythmia
- Arthralgia
- Asthenia
- Bronchospasm
- Gastrointestinal pain
- Pruritus
- Rales
- Vertigo
- Angioedema
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