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NIMODIPINE
SynDRA canonical compound SYN0006441 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CACNA1S |
|---|
| Mechanism of action | Calcium channel blocker |
|---|
| Indication | hemorrhage |
|---|
| Disease area | hematology |
|---|
All known targets
- NR3C2
- CACNA1C
- CACNA1F
- CACNA1S
- CACNA1D
- CFTR
- ABCG2
- Cacna1c
- PDE4D
- PDE1C
- P2RX4
- NR1I2
Mechanisms of action (all sources)
- Calcium channel blocker
- NR3C2 ANTAGONIST
- Mineralocorticoid receptor antagonist
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- CACNA1S ANTAGONIST
- CACNA1F ANTAGONIST
- CFTR POTENTIATOR
- P2RX4 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- ESR2
- PDE1A
- CYP1A2
- CYP2J2
- SLC29A1
- SCN5A
- NR3C1
- MC5R
- HTR2A
- NPY2R
- NPY1R
- NPSR1
- HTR2B
- MPHOSPH8
- MMP9
- MMP1
- HTR2C
- MLNR
- KCNH2
- HTR6
- MC3R
- MAPT
- OPRD1
- MAPK3
- HTR3A
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- MC4R
- OPRM1
- OPRK1
- SIGMAR1
- VDR
- USP1
- TDP1
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADA10
- AHR
- RPGF4
- RAPGEF4
- PRKN
- PRGR
- NSD2
- KCMB4
- KCMB2
- GCR
- ESRRA
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- CACNB2
- CACNA2D1
- ANDR
- TP53
Drug classes
- Calcium Channel Antagonists
- Dihydropyridine Calcium Channel Blocker
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
ATC classes
- C08C · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Cross-references
Synonyms
- NIMOTOP
- NYMALIZE
- Nimotop
- Nymalize
- nemotan
- nymalize
- Nimodipino
- Admon
- Nemotan
- Nimodipine ap
- Periplum
- BAY-E-9736
- NSC-758476
- Brainal
- Calnit
- Kenesil
- Modus
- NimoGel
- NimodipinISIS
- Nimodipinum
- Remontal
- Almirall Brand of Nimodipine
- Alpharma Brand of Nimodipine
- Andromaco Brand of Nimodipine
- Bayer Brand of Nimodipine
- Bayvit Brand of Nimodipine
- Cantabria Brand of Nimodipine
- Elan Brand of Nimodipine
- Esteve Brand of Nimodipine
- Hexal Brand of Nimodipine
- Nimodipin Hexal
- Nimodipin-ISIS
- Nimodipino Bayvit
- Vita Brand of Nimodipine
- Bay-e-9736
- DRG-0139
- EG-1961
Reported adverse events
- Bradycardia
- Nausea
- Tachycardia
- Acne
- Depression
- Headache
- Rash
- Hypotension
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