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DIAZOXIDE
SynDRA canonical compound SYN0006421 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | KCNJ11 |
|---|
| Mechanism of action | Potassium channel activator |
|---|
| Indication | hypoglycemia |
|---|
| Disease area | endocrinology |
|---|
All known targets
- KCNJ11
- KCNJ8
- ABCC8
- ATP1A1
- CA1
- CA2
- KCNMA1
- Kcnj11
- NAMPT
- SLC12A3
Mechanisms of action (all sources)
- Potassium channel activator
- KCNJ11 OPENER
- Potassium channel, inwardly rectifying, subfamily J, member 11 opener
- KCNJ8 OPENER
- Potassium channel, inwardly rectifying, subfamily J, member 8 opener
- ABCC8 OPENER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- MAPK1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAOA
- ADORA1
- LMNA
- LCK
- KCNH2
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH2
- HRH1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- TSHR
- THRB
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMN1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antihypertensive Agents
- Cardiovascular Agents
- Vasodilator Agents
ATC classes
- V03A · ALL OTHER THERAPEUTIC PRODUCTS
- C02D · ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
Cross-references
Synonyms
- HYPERSTAT
- PROGLYCEM
- Proglycem
- dizoxide
- hyperstat
- hypertonalum
- proglicem
- Diazoxido
- Diazoxidum
- Eudemine injection
- Hypertonalum
- NSC-64198
- NSC-76130
- SCH-6783
- SRG-95213
- Eudemine
- Eudimine
- Hyperstat
- Mutabase
- Aroglycem
- Diazossido
- Dizoxide
- Proglicem
- Diazossido [DCIT]
- Diazossido [Italian]
- D 9035
- Sch-6783
- Diazoxido [INN-Spanish]
- Diazoxidum [INN-Latin]
- Hyperstat (TN)
- Diazoxide [USAN:INN:BAN]
- Diazoxide (JAN/USP/INN)
- 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido
- 7-chloro-3-methyl-4H-1
- diazoxide (usp-rs)
- diazoxide (usp monograph)
- diazoxide (ep monograph)
Reported adverse events
- Chest pain
- Hypotension
- Pulmonary hypertension
- Tachycardia
- Diabetic ketoacidosis
- Hirsutism
- Neutropenia
- Thrombocytopenia
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