← SynDRA

8-AZAGUANINE

SynDRA canonical compound SYN0006417 — structure-anchored drug synonym record

All known targets

• PNP

Mechanisms of action (all sources)

• purine antagonist

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ALOX15
• HPRT1
• THRB
• TDP1
• SMARCA2
• SMAD3
• SAMHD1
• POLI
• NFE2L2
• MITF
• MAOB
• MAOA
• KAT2A
• IDH1
• HIF1A
• APOBEC3F
• HDAC6
• HBB
• GMNN
• CYP3A4
• CYP2D6
• CYP2C9
• CYP2C19
• CYP1A2
• CGA
• BRCA1
• ATXN2
• APOBEC3G
• TP53

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ABC3F
• MDR1
• SMCA2

Drug classes

• Antimetabolites, Antineoplastic

Cross-references

• PubChem CID: 135403646
• ChEMBL: CHEMBL374107
• DrugBank: DB01667
• ChEBI: 63486
• PDB: 9QC
• Wikipedia: 8-Azaguanine

Synonyms

• Azaguanine-8
• Guanazolo
• Azaguanine
• Pathocidin
• Guanazol
• Pathocidine
• Triazologuanine
• NSC 749
• SK 1150
• 5-Amino-1H-v-triazolo(d)pyrimidin-7-ol
• SF-337
• 5-Amino-7-hydroxy-1H-v-triazolo(d)pyrimidine
• NSC749
• CHEBI:63486
• 5-Amino-1,6-dihydro-7H-v-triazolo(4,5-d)pyrimidin-7-one
• 5-Amino-1,4-dihydro-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
• NSC223526
• NSC 223526
• 5-Amino-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
• 5-amino-3,6-dihydro-7H-(1,2,3)triazolo(4,5-d)pyrimidin-7-one
• RefChem:388816
• DTXCID1034181
• Azan
• 8 AG
• C4H4N6O
• 5-Amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one
• AZG
• MFCD00056937
• 5-amino-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one
• 2-Amino-6-hydroxy-8-azapurine
• 5-Amino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol
• B-28
• AZAGUANINE,8
• v-Triazolo(4,5-d)pyrimidin-7-ol, 5-amino-
• 5-amino-2,6-dihydrotriazolo[4,5-d]pyrimidin-7-one
• 5-amino-1H-triazolo[4,5-d]pyrimidin-7-ol
• ML068
• 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL