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RG-547
SynDRA canonical compound SYN0006379 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | CCND1 | CCNE1 | CDK1 | CDK2 | CDK4 | CDK7 |
|---|
| Mechanism of action | CDK inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- CDK1 INHIBITOR
- Cyclin-dependent kinase 1 inhibitor
- CDK2 INHIBITOR
- Cyclin-dependent kinase 2 inhibitor
- CDK4/6 inhibitor
- Cyclin-dependent kinase 4 inhibitor
- CDK4 INHIBITOR
- CDK7 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CDKL5
- TAOK1
- CDK14
- CDK13
- CDK12
- CDK11B
- CDK11A
- DMPK
- RPS6KA2
- CASK
- CAMKK2
- DSTYK
- CAMK2G
- CAMK2D
- CAMK2B
- CAMK2A
- DYRK1B
- CDK15
- CDK16
- CDK17
- CLK1
- STK10
- PI4KB
- MAK
- CLK4
- CLK3
- CLK2
- CILK1
- CDK18
- DCLK3
- CDK9
- MAP3K1
- CDK6
- CDK5
- CDK3
- SYK
- DYRK1A
- TAOK2
- MAP4K2
- MAPK7
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CCNB1
- CCND1
- CCNE1
- CP2C9
- CP3A7
- HLAB
- IFNB1
- IFNG
- KSYK
- NSD2
- PARP1
- SNCA
- SYUA
- TP53
Cross-references
Synonyms
- R 547
- Ro-4584820
- RO4584820
- R547
- LIA
- R-547
- [4-amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl]-(2,3-difluoro-6-methoxyphenyl)methanone
- (4-amino-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone
- Ro 4584820
- [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone
- T61871RKRI
- 741713-40-6 (free base)
- (4-Amino-2-((1-methylsulfonylpiperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone
- 5-[(2,3-difluoro-6-Methoxyphenyl)carbonyl]-2-N-(1-Methanesulfonylpiperidin-4-yl)pyriMidine-2,4-diaMine
- (4-Amino-2-{[1-(Methylsulfonyl)piperidin-4-Yl]amino}pyrimidin-5-Yl)(2,3-Difluoro-6-Methoxyphenyl)methanone
- 4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone
- UNII-T61871RKRI
- 2fvd
- (4-amino-2-([1-(methylsulfonyl)piperidin-4-yl]amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone
- MLS006010282
- CHEMBL384304
- GTPL5707
- SCHEMBL2397067
- BDBM12621
- DTXSID30225143
- EX-A105
- HMS3656L13
- 2,4-Diamino-5-ketopyrimidine 39
- BCP02856
- MFCD09970629
- NSC773094
- NSC800859
- s2688
- ZINC13983251
- AKOS025149095
- CCG-269137
- CS-0022
- DB08094
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