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SAXAGLIPTIN ANHYDROUS
SynDRA canonical compound SYN0006378 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DPP4 |
|---|
| Mechanism of action | Dipeptidyl peptidase inhibitor |
|---|
| Indication | diabetes mellitus |
|---|
| Disease area | endocrinology |
|---|
All known targets
- DPP4
- ABCB1
- CYP3A4
- CYP3A5
- DPP8
- DPP9
- SLC5A2
Mechanisms of action (all sources)
- Dipeptidyl peptidase inhibitor
- DPP4 inhibitor
- DPP4 MODULATOR
- SLC5A2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- HTR1A
- MAPK1
- MAOA
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HRH3
- ADORA1
- HRH2
- HRH1
- HDAC6
- GSK3B
- GHSR
- FGFR2
- FAP
- MC3R
- MLNR
- NPY1R
- NR1I2
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SCN5A
- PTGS2
- PREP
- PPARG
- PGR
- PDE4D
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- ESR1
- EDNRA
- DRD3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Dipeptidyl-Peptidase IV Inhibitors
- Enzyme Inhibitors
- Hormones
- Hypoglycemic Agents
- Incretins
- Protease Inhibitors
ATC classes
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- DAPAGLIFLOZIN AND SAXAGLIPTIN HYDROCHLORIDE
- KOMBIGLYZE XR
- ONGLYZA
- Onglyza
- QTERN
- QTERNMET XR
- Qtern
- SAXAGLIPTIN
- SAXAGLIPTIN AND METFORMIN HYDROCHLORIDE
- saxagliptin
- onglyza
- saxagliptin hydrochloride
- saxagliptin hydrate
- saxagliptin HCl
- BMS 477118
- BMS-477118
- SBMS-477118
- Saxagliptin
- BMS-477118-11
- Kombiglyze XR (TN)
- OPC-262
- Onglyza (TN)
- Dapagliflozin Propanediol; Saxagliptin Hydrochloride
- Saxagliptin Hydrochloride
- Saxagliptin [INN]
- OPC 262
- 8I7IO46IVQ
- CHEMBL385517
- CHEBI:71272
- BMS477118
- UNII-8I7IO46IVQ
- Saxagliptine
- Saxagliptin (BMS-477118,Onglyza)
- HSDB 8199
- NCGC00242597-01
- SAXAGLIPTIN [MI]
- Saxagliptin (USAN/INN)
- SCHEMBL17168
- SAXAGLIPTIN [WHO-DD]
Reported adverse events
- Headache
- Urinary tract infection
- Arthralgia
- Upper respiratory tract infection
- Hypersensitivity
- Pancreatitis
- Infection
- Rhabdomyolysis
- Rash
- Escherichia urinary tract infection
- Nasopharyngitis
- Back pain
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