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SIBUTRAMINE
SynDRA canonical compound SYN0006345 — structure-anchored drug synonym record
| Approval status | Approved · OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Serotonin reuptake inhibitor |
|---|
All known targets
- SLC6A2
- SLC6A4
- SLC6A3
- CYP2B6
- ADRA2B
- ADRA2C
- KCND3
- Kcnd3
- SLC22A2
Mechanisms of action (all sources)
- Serotonin reuptake inhibitor
- SLC6A4 INHIBITOR
- Monoamine transporter inhibitor
- SLC6A3 INHIBITOR
- SLC6A2 INHIBITOR
- CYP2B6 INHIBITOR
- SLC6A2 MODULATOR
- SLC6A4 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- HTR2A
- ADRA2A
- OPRK1
- MAPK14
- LCK
- LMNA
- MAOA
- MAPK1
- ACHE
- MAPK3
- IDH1
- MC3R
- MC4R
- MC5R
- MLNR
- MAPT
- HTR6
- MMP9
- HTR3A
- HTR2C
- HTR2B
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- HCAR2
- GMNN
- GLP1R
- MMP1
- NPY1R
- GHSR
- PTPRC
- TSHR
- TDP1
- TBXAS1
- TBXA2R
- TACR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- LOX15
Drug classes
- Norepinephrine Uptake Inhibitors
- Serotonin Uptake Inhibitors
- Dopamine Uptake Inhibitors
- Norepinephrine, Serotonin, and Dopamine Reuptake Inhibitor Anorectic
- Anti-Obesity Agents
- Antidepressive Agents
- Appetite Depressants
- Central Nervous System Agents
- Psychotropic Drugs
ATC classes
- A08A · ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
Cross-references
Synonyms
- MERIDIA
- (+/-)-Sibutramine
- didemethyl sibutramine hydrochloride
- racemic sibutramine
- sibutramine hydrochloride
- sibutramine hydrochloride hydrate
- BTS 54524
- didemethyl sibutramine HCl
- sibutramine HCl
- didesmethylsibutramine
- Sibutramina
- Butramin
- Cf-alli
- Medaria
- Racemic sibutramine
- Reductil
- Meridia
- Sibutraminum
- Sibutramina [Spanish]
- Sibutraminum [Latin]
- BTS-54524
- Butramin (TN)
- Ectiva (TN)
- Meridia (TN)
- Reductil (TN)
- Sibutramine (INN)
- Sibutramine [INN:BAN]
- WV5EC51866
- HSDB 7209
- RefChem:931716
- DTXCID603578
- A08AA10
- DEA No. 1675
- SIBUTRAMINE [INN]
- C17H26ClN
- SMR000238156
- UNII-WV5EC51866
- S-Sibutramine
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