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BENZAMIL
SynDRA canonical compound SYN0006290 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | PKD2L1 |
|---|
| Mechanism of action | Sodium channel blocker |
|---|
All known targets
- PKD2L1
- SCNN1A
- SCNN1B
- SCNN1G
- SCNN1D
- ASIC1
- SLC8A1
- ASIC3
Mechanisms of action (all sources)
- Sodium channel blocker
- ASIC1 MODULATOR
- SCNN1A MODULATOR
- SCNN1B MODULATOR
- SCNN1G MODULATOR
- PKD2L1 MODULATOR
- PKD2L1 BLOCKER (CHANNEL BLOCKER)
- ASIC3 BLOCKER (CHANNEL BLOCKER)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- FTO
- ALDH1A1
- MAPT
- MPG
- MPHOSPH8
- MUTYH
- NEIL1
- NEIL2
- NFE2L2
- NFKB1
- NPC1
- NPSR1
- NTHL1
- OGG1
- PMP22
- POLI
- SAMHD1
- SLCO1B1
- SLCO1B3
- SMPD1
- SMUG1
- TDG
- TDP1
- THPO
- UNG
- MBD4
- KDM4E
- ALOX15B
- EHMT2
- APEX1
- ARSA
- ATXN2
- BLM
- CYP1A2
- CYP2C19
- CYP2C9
- CYP2D6
- CYP3A4
- DRD1
- FEN1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AHR
- CP1A2
- CP2D6
- IL1B
- KSYK
- NSD2
- NTM1A
- PK2L1
- RAD52
- STK33
- SYK
- TPO
Cross-references
Synonyms
- UNII-04659UUJ94
- N-(N-Benzylamidino)-3,5-diamino-6-chloropyrazine carboxamide
- GNF-Pf-192
- CHEMBL212579
- CHEBI:34558
- 04659UUJ94
- 3,5-Diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)pyrazinecarboxamide
- 3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide
- Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)-
- Spectrum3_001823
- Prestwick1_000657
- Prestwick3_000657
- Prestwick2_000657
- Prestwick0_000657
- Lopac-B-2417
- AC1L33CQ
- Lopac0_000211
- KBioGR_000300
- benzamil amiloride
- RefChem:117161
- DTXCID50105670
- Benzylamiloride
- N-(benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide
- MFCD12910437
- C13H14ClN7O
- BenzamilHCl
- BSPBio_000693
- BSPBio_001580
- BSPBio_003465
- KBioSS_000300
- DivK1c_001001
- SCHEMBL412783
- SPBio_002614
- BPBio1_000763
- GTPL4145
- orb1301433
- SCHEMBL4242779
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