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POSACONAZOLE
SynDRA canonical compound SYN0006043 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 | CYP51A1 |
|---|
| Mechanism of action | sterol demethylase inhibitor |
|---|
| Indication | oropharyngeal candidiasis |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP3A4
- ABCG2
- CYP51
- CYP51A1
- CYP8B1
- Candi ERG11
- ERG11
- cyp51A
- cyp51B
Mechanisms of action (all sources)
- sterol demethylase inhibitor
- Candi ERG11 INHIBITOR
- ERG11 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYP11B1
- CYP11B2
- ABCB11
- PTGS2
- ESR1
- NR1I2
- CYP2C9
- CYP19A1
- CYP17A1
- KCNH2
- MAOA
- MC3R
- OPRD1
- ABCB1
- HTR1A
- OPRM1
- PDE3A
- PDE4A
- PDE4D
- PGR
- PTGS1
- SLC6A2
- SLC6A3
- SLC6A4
- HTR2B
- HDAC6
- HRH3
- HRH1
- ACHE
- ADORA1
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- AR
- CHRM1
- CHRM2
- DRD1
- DRD3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP2C9
- CP2CJ
- CP3A4
- CP3A7
- ESR2
- ESRRA
- GLI3
- GPR32
- KSYK
- NF2L2
- RARA
- SYK
- TSHR
Drug classes
- Azole Antifungal
- 14-alpha Demethylase Inhibitors
- Anti-Infective Agents
- Antifungal Agents
- Antiparasitic Agents
- Antiprotozoal Agents
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Hormone Antagonists
- Metabolic Side Effects of Drugs and Substances
- Steroid Synthesis Inhibitors
- Trypanocidal Agents
ATC classes
- J02A · ANTIMYCOTICS FOR SYSTEMIC USE
Cross-references
Synonyms
- NOXAFIL
- NOXAFIL POWDERMIX KIT
- Noxafil
- noxafil
- posaconazol
- SCH-56592
- Posaconazol
- (-)-posaconazole
- Noxafil powdermix kit
- Posaconazole accord
- Posaconazole ahcl
- Posaconazole sp
- Spriafil
- Posaconazole SP
- Posaconazole in combination with MGCD290
- SCH56592
- X2N
- Noxafil (TN)
- Noxafil, Posaconazole
- Posaconazole (USAN/INN)
- Posaconazole [USAN:INN:BAN]
- Schering 56592
- (-)-POSACONAZOLE
- 6TK1G07BHZ
- CHEMBL1397
- CHEBI:64355
- POS
- UNII-6TK1G07BHZ
- pasaconazole
- HSDB 7421
- Posaconazole- Bio-X
- Posaconazole - Form I
- Posaconazole - Form III
- POSACONAZOLE [MI]
- POSACONAZOLE [INN]
- POSACONAZOLE [JAN]
- POSACONAZOLE [HSDB]
Reported adverse events
- Cough
- Hypersensitivity
- Hypertension
- Nausea
- Rash
- Thrombocytopenia
- Vomiting
- Arrhythmia
- Asthenia
- Constipation
- Epistaxis
- Headache
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