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NECROSTATIN
SynDRA canonical compound SYN0006012 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | RIPK1 |
|---|
| Mechanism of action | RIPK inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- RIPK inhibitor
- IDO1 INHIBITOR
- RIPK1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- AHR
- CYP3A4
- GLA
- HDAC6
- HSD17B10
- MAPT
- MLKL
- RIPK2
- RIPK3
- SMN1
- THRB
- TP53
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP3A4
- I23O1
- KSYK
- NR1I3
- SMN
- SYK
Cross-references
Synonyms
- NECROSTATIN-1
- Necrostatin-1
- Nec-1 compound
- RefChem:927559
- DTXCID90336209
- MTH-DL-Tryptophan
- 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone
- Nec-1
- MFCD00056916
- MTH-trp
- methyl-thiohydantoin-tryptophan
- Methylthiohydantoin-DL-tryptophan;MTH-DL-tryptophan
- Necrostatin-1?
- MTH-trp;
- Necrostatin-1 5-(1
- Nec-1;
- Oprea1_645908
- CBDivE_006695
- MLS006011643
- SCHEMBL856922
- GTPL9750
- orb1307335
- methylthiohydantoin-DL-tryptophan
- SCHEMBL29351522
- BDBM36371
- CHEBI:91658
- TXUWMXQFNYDOEZ-UHFFFAOYSA-N
- HMS3229H21
- HMS3268N04
- HMS3413G04
- HMS3653J04
- HMS3673K15
- HMS3677G04
- EX-A2108
- Necrostatin-1, >=98% (HPLC)
- s8037
- STL511330
- AKOS001662677
- AKOS016050497
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