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TOLTERODINE
SynDRA canonical compound SYN0005886 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CHRM4 |
|---|
| Mechanism of action | Acetylcholine receptor antagonist |
|---|
| Indication | urinary frequency | urinary incontinence |
|---|
| Disease area | urology |
|---|
All known targets
- CHRM3
- CHRM2
- CHRM1
- CHRM4
- CHRM5
- Chrm1
- Chrm2
- Chrm3
- Chrm4
- Chrm5
- KCNH2
Mechanisms of action (all sources)
- Acetylcholine receptor antagonist
- CHRM3 ANTAGONIST
- Muscarinic acetylcholine receptor M3 antagonist
- CHRM2 ANTAGONIST
- Muscarinic acetylcholine receptor M2 antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH2
- ADRB2
- OPRK1
- FFAR4
- CX3CR1
- SIGMAR1
- SCN5A
- HRH1
- ADRA1A
- HTR2A
- TMEM97
- HTR2B
- MAPT
- NEIL2
- NEIL1
- MUTYH
- MPG
- MLNR
- MC4R
- MC3R
- MAOA
- HTR1D
- HTR2C
- LMNA
- KDR
- KCND3
- IDH1
- HTR7
- HTR6
- HTR3A
- NPY1R
- NTSR1
- NPY2R
- PTGS2
- TDP1
- TDG
- TBXA2R
- TACR1
- SLC6A4
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- ITA4
- NSD2
- NR1I2
- KCMB4
- KCMB1
- KCMA1
- JUN
- HXA9
- ACM4
- GLI3
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- ACM5
- TRHR
Drug classes
- Cholinergic Muscarinic Antagonists
- Cholinergic Agents
- Cholinergic Antagonists
- Muscarinic Antagonists
- Neurotransmitter Agents
- Urological Agents
- Cholinergic Muscarinic Antagonist
ATC classes
Cross-references
Synonyms
- DETROL
- DETROL LA
- Detrol
- TOLTERODINE TARTRATE
- tolterodine tartrate
- (+)-Tolterodine
- (R)-Tolterodine
- Tolterodina
- KABI-2234
- Blerone xl
- Detrusitol
- Detrusitol xl
- Efflosomyl xl
- Inconex xl
- Mariosea xl
- Neditol xl
- Preblacon xl
- Santizor xl
- Tolterodinum
- Detrol (TN)
- Detrusitol (TN)
- Kabi-2234
- WHE7A56U7K
- (+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol
- CHEBI:9622
- RefChem:56377
- G04BD07
- (R)-(+)-Tolterodine
- Tolterodine [INN]
- R-(+)-Tolterodine
- Tolterodinum [INN-Latin]
- Tolterodina [INN-Spanish]
- Urotrol
- NCGC00159519-02
- tolterodin
- DTXCID703687
- Unidet
- Tolterodine (racemate)
Reported adverse events
- Dry mouth
- Dry skin
- Dyspepsia
- Dysuria
- Fatigue
- Headache
- Vertigo
- Arthralgia
- Chest pain
- Constipation
- Influenza
- Somnolence
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