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PROGUANIL
SynDRA canonical compound SYN0005858 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP2C19 | DHFR |
|---|
| Mechanism of action | dihydrofolate reductase inhibitor |
|---|
| Indication | malaria |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP2C19
- DHFR
- PDF
- Taar1
- Dhfr
- folA
- dfrA17
Mechanisms of action (all sources)
- dihydrofolate reductase inhibitor
- PDF INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD1
- SLC6A2
- ACHE
- LMNA
- MAOA
- OPRM1
- PDE3A
- PDE4A
- PGR
- POLI
- PTGS1
- RAPGEF3
- KCNH2
- SAMHD1
- SLC47A1
- SLC47A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- TBXA2R
- KDR
- IDH1
- ADORA3
- CYP2D6
- ADRA1A
- ADRA2A
- AR
- ATAD5
- CHRM1
- CHRM2
- CYP1A2
- CYP2C9
- CYP3A4
- HTR2B
- DRD3
- ESR1
- F2
- GLP1R
- GMNN
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- ANDR
- CP1A2
- CP2CJ
- CP2D6
- ESRRA
- GLI3
- PRGR
Drug classes
- Dihydrofolate Reductase Inhibitors
- Antimalarial
- Anti-Infective Agents
- Antimalarials
- Antimetabolites
- Antiparasitic Agents
- Antiprotozoal Agents
- Noxae
- Enzyme Inhibitors
- Folic Acid Antagonists
ATC classes
Cross-references
Synonyms
- ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
- MALARONE
- MALARONE PEDIATRIC
- proguanil hydrochloride
- chloroguanide
- chloroguanide hydrochloride
- proguanil HCl
- chloroguanide HCl
- Chlorguanide
- Chloroguanide
- Bigumal
- Chlorguanid
- Chloriguane
- Paludrin
- Proguanile
- Proguanilum
- Proguanile [DCIT]
- Diguanyl (hydrochloride)
- Drinupal (hydrochloride)
- Paludrine (TN)
- Paludrine (hydrochloride)
- Palusil (hydrochloride)
- Proguanil [INN:BAN]
- Proguanilum [INN-Latin]
- RP-3359
- Tirian (hydrochloride)
- M-4888 (hydrochloride)
- SN-12837 (hydrochloride)
- N1-p-Chlorophenyl-N5-isopropylbiguanide
- N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide
- 1-(p-Chlorophenyl)-5-isopropylbiguanide
- 1-Isopropyl-5-(4-chlorophenyl)biguanide
- MFCD00866201
- N1-(4-Chlorophenyl)-N5-isopropylbiguanide
- Proguanil?
- SCHEMBL45726
- SCHEMBL45727
- SCHEMBL45728
Reported adverse events
- Anxiety
- Dizziness
- Insomnia
- Nausea
- Pruritus
- Vomiting
- Abdominal pain
- Depression
- Headache
- Neutropenia
- Pancytopenia
- Stevens-Johnson syndrome
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