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NOSCAPINE
SynDRA canonical compound SYN0005857 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | SIGMAR1 |
|---|
| Mechanism of action | Bradykinin receptor antagonist |
|---|
| Indication | cough suppressant |
|---|
| Disease area | pulmonary |
|---|
All known targets
- SIGMAR1
- BDKRB2
- CYP2C19
- CYP2C9
- SLC22A2
- SLC47A1
Mechanisms of action (all sources)
- microtubule inhibitor
- Bradykinin receptor antagonist
- tubulin polymerization inhibitor
- bradykinin receptor antagonist, tubulin polymerization inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- GHSR
- NR1I2
- PTGS2
- AGTR1
- ADRB1
- MC5R
- MAPK3
- MC3R
- MC4R
- MLNR
- MAPK1
- MMP1
- MMP9
- NFE2L2
- NPY1R
- NPY2R
- MAPK14
- LCK
- MAOA
- NTSR1
- KCNH2
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- NR3C1
- OPRK1
- OPRD1
- SLC29A1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- TUBA3E
- TUBB8
- TUBB6
- TUBB4B
- TUBB4A
- TUBB3
- TUBB2B
- TUBB2A
- TUBB1
- TUBB
- TUBA4A
- TUBA3C
- CP2CJ
- TUBA1C
- TUBA1B
- TUBA1A
- TP53
- SENP8
- PE2R2
- NPR2
- CP3A7
- CP3A4
- CP2D6
- TUBB8B
Drug classes
- Antitussive Agents
- Central Nervous System Agents
- Respiratory System Agents
ATC classes
- R05D · COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Cross-references
Synonyms
- methoxyhydrastine
- narcompren
- narcosine
- noscapalin
- noscapin
- terbenol
- vadebex
- noscapine hydrochloride
- noscapine HCl
- Noscapina
- (-)-.alpha.-narcotine
- (-)-narcotine
- Methoxyhydrastine
- Narcotinum
- Noscapinum
- NSC-5366
- CB3304
- NARCOTINE
- Tusscapine
- Terbenol
- Coscopin
- Narcompren
- Narcosine
- Vadebex
- Noscapalin
- Longatin
- Opianine
- (-)-Narcotine
- Narcotin
- Narcotussin
- Nectadon
- Nicolane
- Noscapin
- Lyobex
- Nipaxon
- Opianin
- Opian
- Coscotabs
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