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ALFAXALONE

SynDRA canonical compound SYN0005856 — structure-anchored drug synonym record

All known targets

• GABBR1
• GABRA1
• Gabrq
• Gabrp
• Gabrg3
• Gabrg2
• Gabrg1
• Gabre
• Gabrd
• Gabrb3
• Gabrb2
• Gabrb1

Mechanisms of action (all sources)

• GABA receptor agonist
• Chloride channel agonist

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• CYP3A4
• EHMT2
• GLA
• HDAC6
• KCNK9
• NFE2L2
• POLI
• SAMHD1
• SMN1
• SNCA
• TDP1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ANDR
• CP2C9
• CP3A7
• ESRRA

Drug classes

• Anesthetics
• Central Nervous System Agents
• Central Nervous System Depressants
• Neurosteroids
• Neurotransmitter Agents

ATC classes

• N01A · ANESTHETICS, GENERAL

Cross-references

• PubChem CID: 104845
• ChEMBL: CHEMBL190279
• DrugBank: DB11371
• ChEBI: CHEBI:34531
• KEGG: D07282
• RxNorm: 1544577
• PDB: EY4
• Wikipedia: Alfaxalone
• TTD: D06UBH
• LINCS BRD: BRD-K41445866

Synonyms

• Alfaxan
• alfaxolone
• alfadione
• alphaxalone
• Alfaxalona
• Alphaxolone
• Phaxan
• GR-2/234
• Alphaxalone
• 5alpha-Pregnan-3alpha-ol-11,20-dione
• GR 2/234
• Alfaxalonum [INN-Latin]
• Alfaxalona [INN-Spanish]
• 3alpha-Hydroxy-5alpha-pregnane-11,20-dione
• UNII-BD07M97B2A
• BRN 3217240
• MLS001076262
• MLS000069684
• 3alpha-Hydroxy-5alpha-pregnan-11,20-dion
• BD07M97B2A
• CHEMBL190279
• CHEBI:34531
• 3-alpha-Hydroxy-5-alpha-pregnane-11,20-dione
• (3-alpha,5-alpha)-3-Hydroxypregnane-11,20-dione
• 3-Hydroxypregnane-11,20-dione
• NCGC00023100-03
• SMR000058494
• (3a,5a)-3-Hydroxypregnane-11,20-dione
• Alfaxalonum
• Alfadione
• DTXCID702576
• delta(16)-alfaxalone
• Alfaxan Multidose
• hydroxy-5 alpha-pregnane-11,20-dione
• RefChem:57111
• ALFAXAN MULTIDOSE IDX
• N01AX05