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PALBOCICLIB
SynDRA canonical compound SYN0005849 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CDK6 |
|---|
| Mechanism of action | CDK inhibitor |
|---|
| Indication | breast cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- CDK4
- CDK6
- CCND1
- AAK1
- JAK3
- TAOK2
- STK16
- RPS6KA1
- PRKD3
- PRKD2
- PIP4K2C
- PIP4K2A
Mechanisms of action (all sources)
- cyclin-dependent kinase inhibitor
- CCND1 INHIBITOR
- CDK6/cyclin D1 inhibitor
- CDK4/6 inhibitor
- Cyclin-dependent kinase 4/cyclin D1 inhibitor
- CDK4 MODULATOR
- CDK6 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CDK1
- PDE4D
- DAPK3
- CSNK2B
- LRRK2
- CSNK2A1
- ROCK2
- TAOK1
- SYK
- KCNH2
- NEK2
- CLK4
- CLK2
- PDE5A
- CAMK2B
- MST1R
- CAMK2D
- CAMK2G
- PDE4A
- CHRNA4
- CHRM3
- CHRM2
- STING1
- CHRM1
- CHEK1
- PARP1
- PAK4
- OPRM1
- ALK
- CDK5
- RET
- MED23
- PRKX
- MET
- ACHE
- PNCK
- PKN1
- PKN2
- PKN3
- PLK1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AAPK1
- DYR1A
- MK09
- MK08
- M4K5
- M4K4
- M4K2
- KSYK
- KS6A3
- KPCD3
- IFNB1
- DYR1B
- CP3A7
- CCNA1
- CDK5R1
- CCNT2
- CCNT1
- CCNK
- CCNE2
- CCNE1
- CCND2
- CCNB3
- CCNB2
- CCNB1
- NSD2
Drug classes
- Kinase Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Protein Kinase Inhibitors
- Kinase Inhibitor
- Cytochrome P450 3A Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- IBRANCE
- Ibrance
- palbociclib isethionate
- ibrance
- PD 0332991
- PD-0332991-0054
- PF-00080665-73
- Palbociclib isethionate
- PALBOCICLIBPD-0332991PD0332991IBRANCECS-0019A-1030
- PD-0332991
- PD-03329910054
- PD0332991
- PF-0008066573
- PFE-PKIS 32
- PFE-PKIS_32
- UNII-G9ZF61LE7G
- Palbociclib(PD0332991)
- G9ZF61LE7G
- PD 332991
- LQQ
- PD 332991, PD 0332991, PD0332991
- HMR-2934
- Palbociclib free base
- 571190-30-2 (free base)
- MFCD11840850
- CHEBI:85993
- 2euf
- Palbociclib [USAN]
- 571190-30-2 pound not827022-32-2
- Palbociclib [USAN:INN]
- [d8]-Palbociclib
- Ibrance (TN)
- Palbociclib- Bio-X
- Kinome_3823
- Kinome_3824
- PALBOCICLIB [MI]
- PALBOCICLIB [INN]
Reported adverse events
- Alopecia
- Asthenia
- Blood creatinine
- Blood creatinine increased
- Dry skin
- Dysgeusia
- Fatigue
- Infection
- Interstitial lung disease
- Leukopenia
- Nausea
- Neutropenia
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