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NUTLIN-3

SynDRA canonical compound SYN0005819 — structure-anchored drug synonym record

All known targets

• MDM2
• TP53

Mechanisms of action (all sources)

• MDM inhibitor
• TP53 INHIBITOR
• MDM2 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• MDM4
• BCL2
• HDAC1
• HIF1A
• MCL1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• KSYK
• NSD2
• SYK

Cross-references

• PubChem CID: 216345
• ChEMBL: CHEMBL191334
• DrugBank: DB17039
• ChEBI: 93777
• PDB: NUT
• TTD: D01QKK

Synonyms

• nutlin 3
• nutlin-3A
• (+/-)-Nutlin3
• CHEMBL211045
• Nutlin 3(Random Configuration)
• MDM2 Antagonist, Nutlin-3, Racemic
• 4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
• 4-({4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one
• 4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
• REBEMADLIN
• Nutlin 3
• NSC 732664
• CHEBI:46742
• RefChem:878998
• DTXCID101767048
• Nutlin 3a
• (-)-Nutlin 3
• MFCD14636430
• L7C92IOE65
• C30H30Cl2N4O4
• UNII-L7C92IOE65
• Nutlin-3a?
• 4hg7
• 4j3e
• REBEMADLIN [INN]
• (4S,5R)-Nutlin-3
• UNII-53IA0V845C
• orb1301142
• SCHEMBL1155752
• SCHEMBL29375546
• CHEBI:95096
• BDUHCSBCVGXTJM-WUFINQPMSA-N
• GLXC-05552
• HMS3649P17
• Nutlin-3a, >=98% (HPLC)
• EX-A1359
• SML-0580
• BDBM50229787
• NSC756875