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ACEMETACIN
SynDRA canonical compound SYN0005746 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | osteoarthritis |
|---|
| Disease area | rheumatology |
|---|
All known targets
- PTGS1
- PTGS2
- GLO1
- PTGDR2
- PPARG
- SLC46A1
- PLA2G2A
- PPARA
- PTGR2
- Ptgs2
- ABCB1
- ABCC1
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- PTGDR2 FULL AGONIST
- PPARG PARTIAL AGONIST
- SLC46A1 INHIBITOR
- PTGS2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD3
- ACHE
- LCK
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- KCNH2
- FYN
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HIF1A
- NPY2R
- NR1I2
- NR3C1
- SIGMAR1
- TBXAS1
- TBXA2R
- TARDBP
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CFTR
- MCL1
- MDR1
- MLP3A
- PAFA
- PPARG
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Cyclooxygenase Inhibitors
- Cardiovascular Agents
- Enzyme Inhibitors
- Gout Suppressants
- Reproductive Control Agents
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- C01E · OTHER CARDIAC PREPARATIONS
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- S01B · ANTIINFLAMMATORY AGENTS
- ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Cross-references
Synonyms
- Bay f 4975
- TVX 1322
- acemet
- acemethacin
- acemethazine
- rantudil
- Acemetacine
- Acemetacina
- Rantudil
- NSC-757413
- Emflex
- Acemix
- Acemetacinum
- TVX 3322
- K 708
- indomethacin carboxymethyl ester
- indometacin glycolic ester
- indomethacin glycolic ester
- indometacin carboxymethyl ester
- NSC 757413
- 5V141XK28X
- DTXCID402540
- CHEBI:31162
- RefChem:551465
- M01AB11
- TVX-1322
- MFCD00151473
- TV-1322
- Rheumibis
- NCGC00016868-09
- Aximeixin
- CAS-53164-05-9
- C21H18ClNO6
- Bay-f-4975
- Acemetacine [INN-French]
- Acemetacinum [INN-Latin]
- Acemetacina [INN-Spanish]
- SMR000058409
Reported adverse events
- Bleeding
- GI bleed
- Perforation
- Ulceration
- Elderly
- Thrombophlebitis
- Stevens-Johnson syndrome
- Hypertension
- Headache
- Hepatotoxicity
- Pruritus
- Asthma
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