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FULVESTRANT
SynDRA canonical compound SYN0005617 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ESR1 |
|---|
| Mechanism of action | Estrogen receptor antagonist |
|---|
| Indication | breast cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- ESR1
- EPHX2
- ESR2
- GPER1
- ESRRA
- Esr1
- NR1H4
- NR1I2
- PGR
- SIRT5
- bla
- blaT-3
Mechanisms of action (all sources)
- ESR1 ANTAGONIST
- ESR1 DEGRADER
- ESR2 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR3C1
- ABL1
- MLNR
- MAPK1
- MAOA
- KCNH2
- KAT2A
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HSD17B7
- HRH3
- HRH2
- HRH1
- HDAC6
- MC3R
- NFE2L2
- GHSR
- SAMHD1
- TDP1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SCN5A
- PTGS2
- NPY1R
- PPARG
- PDE4D
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- GSK3B
- GALC
- ADORA1
- FGFR2
- BDKRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP19A
- CP2C9
- CP2CJ
- CP3A4
- CRBN
- GCR
- GLI3
- IFNG
- NF2L2
- PRGR
Drug classes
- Estrogen Receptor Antagonists
- Selective Estrogen Receptor Modulators
- Estrogen Receptor Antagonist
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Estrogen Antagonists
- Hormone Antagonists
ATC classes
- L02B · HORMONE ANTAGONISTS AND RELATED AGENTS
Cross-references
Synonyms
- CLIGAVYX
- FASLODEX
- Faslodex
- ZD9238
- faslodex
- ICI 182,780
- ICI-182780
- NSC-759879
- ZD-9238
- Fulvestrant mylan
- AstraZeneca brand of fulvestrant
- Fulvestrant [USAN]
- Ici 182780
- ZD-182780
- ZM-182780
- Faslodex (TN)
- Faslodex(ICI 182,780)
- Faslodex, ICI 182780, Fulvestrant
- Fulvestrant (JAN/USAN/INN)
- ICI
- ZD 9238
- Fulvestrant (Faslodex)
- CHEMBL1358
- CHEBI:31638
- 22X328QOC4
- NSC 759879
- C32H47F5O3S
- CAS-129453-61-8
- ICI182780
- fulvestrantum
- Fluvestrant
- UNII-22X328QOC4
- CCRIS 8741
- HSDB 7658
- NCGC00024964-02
- Fulvestrant [USAN:USP:INN:BAN]
- MFCD00903953
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