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VALACYCLOVIR
SynDRA canonical compound SYN0005536 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Mechanism of action | DNA polymerase inhibitor |
|---|
| Indication | shingles | virus herpes simplex (HSV) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- HSV UL30
- PNP
- VZV ORF28
- punA
- TK
Mechanisms of action (all sources)
- DNA polymerase inhibitor
- HSV UL30 INHIBITOR
- HSV UL30 MODULATOR
- VZV ORF28 MODULATOR
- TK INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC2
- GIPR
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KCNH2
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- HCAR2
- OPRD1
- OPRK1
- OPRM1
- SLC22A8
- USP1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- DNA Polymerase Inhibitors
- Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
- Anti-Infective Agents
- Antiviral Agents
- Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
- Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor
- Enzyme Inhibitors
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
- S01A · ANTIINFECTIVES
- D06B · CHEMOTHERAPEUTICS FOR TOPICAL USE
Cross-references
Synonyms
- VALACYCLOVIR HYDROCHLORIDE
- VALTREX
- Valtrex
- valaciclovir
- valcivir
- valacyclovir hydrochloride
- valacyclovir HCl
- Valaciclovir
- Valacv
- Talavir
- VACV
- ValACV
- Virval
- Zelitrex
- Valaciclovir Hcl
- Valacyclover Hydrochloric
- Valacyclover Hydrochloride
- BW256U87
- TBB067866
- Acyclovir-valine
- BW-256U
- Valaciclovir (INN)
- Valaciclovir [INN:BAN]
- Valaciclovir, Valtrex
- Valtrex (TN)
- Zelitrex (TN)
- Valacyclovir, (L)-isomer
- L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine
- L-VALINE, ESTER WITH 9-((2-HYDROXYETHOXY)METHYL)GUANINE
- MZ1IW7Q79D
- Val-ACV
- CHEBI:35854
- Valaciclovirum
- L Valylacyclovir
- L-valyl Ester Acyclovir
- RefChem:56196
- Acyclovir, L valyl Ester
- DTXCID403732
Reported adverse events
- Myalgia
- Alopecia
- Renal failure
- Erythema multiforme
- Thrombocytopenia
- Pruritus
- Purpura
- Abdominal pain
- Disseminated intravascular coagulation
- Erythema
- Stevens-Johnson syndrome
- Lethargy
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