← SynDRA
ORLISTAT
SynDRA canonical compound SYN0005491 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | LIPF |
|---|
| Mechanism of action | Lipase inhibitor |
|---|
| Indication | weight-loss aid |
|---|
| Disease area | endocrinology |
|---|
All known targets
- PNLIP
- LIPF
- CNR1
- DAGLA
- FASN
- DAGLB
- ABHD12
- ABHD16A
- ABHD6
- Dagla
- Faah
- LIPC
Mechanisms of action (all sources)
- Lipase inhibitor
- LIPF INHIBITOR
- Gastric lipase inhibitor
- PNLIP INHIBITOR
- Pancreatic lipase inhibitor
- CNR1 INHIBITOR
- PNLIP MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- NR1I2
- PSMB1
- NCEH1
- NPC1L1
- OPRM1
- PDE3A
- PDE4A
- PGR
- PNLIPRP2
- POLI
- POLK
- PSMB2
- MAPT
- PSMB5
- PTGS1
- RAPGEF3
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- TBXA2R
- TDP1
- MGLL
- MAOA
- ADORA3
- CYP2D6
- ADRA1A
- ADRA2A
- AR
- ATXN2
- CBX1
- CEL
- CHRM1
- CHRM2
- CNR2
- CYP2C9
- CYP3A4
- KDR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- CP1A2
- TNNI3
- TNNC1
- PRGR
- PAFA2
- PAFA
- NAPEP
- IFNG
- GCR
- FAS
- ESR2
- DGLB
- DGLA
- CP3A7
- CP3A4
- CP2C9
- TNNT2
Drug classes
- Lipase Inhibitors
- Intestinal Lipase Inhibitor
- Anti-Obesity Agents
- Enzyme Inhibitors
- Lipid Regulating Agents
ATC classes
- A08A · ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
Cross-references
Synonyms
- ALLI
- Alli
- XENICAL
- Xenical
- tetrahydrolipstatin
- xenical
- alli
- tetrahydrolipastatin
- Lipstatin
- Orlipastat
- Tetrahydrolipstatin
- NSC-758881
- RO-18-0647/002
- RO-180647-002
- RO-180647002
- Ro-18-0647-002
- Alli (previously orlistat gsk)
- Beacita
- (-)-Tetrahydrolipstatin
- Orlipastatum
- Orlipastatum [INN-Latin]
- THLP
- Ro-18-0647
- UNII-95M8R751W8
- C29H53NO5
- Ro 18-0647/002
- Orlistat (Alli, Xenical)
- MLS002207022
- CHEMBL175247
- GlaxoSmithKline brand of orlistat
- Roche brand of orlistat
- Alli (TN)
- Hoffmann-La Roche brand of orlistat
- KS-1183
- Orlistat [USAN:INN]
- R-212
- Xenical (TN)
- Orlistat (USAN/INN)
Look up ORLISTAT in the interactive SynDRA portal →