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DARIFENACIN
SynDRA canonical compound SYN0005484 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CHRM5 |
|---|
| Mechanism of action | Acetylcholine receptor antagonist |
|---|
| Indication | urinary incontinence |
|---|
| Disease area | urology |
|---|
All known targets
- CHRM3
- CHRM2
- CHRM1
- CHRM4
- CHRM5
- ADRB1
- ADRB2
- Chrm2
- Chrm3
- DRD2
Mechanisms of action (all sources)
- Acetylcholine receptor antagonist
- CHRM3 ANTAGONIST
- Muscarinic acetylcholine receptor M3 antagonist
- CHRM2 ANTAGONIST
- Muscarinic acetylcholine receptor M2 antagonist
- CHRM1 ANTAGONIST
- CHRM2 INVERSE AGONIST
- CHRM4 ANTAGONIST
- CHRM5 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2A
- SCN5A
- HTR2B
- HRH2
- GHSR
- OPRK1
- OPRM1
- KCNH2
- ADRA2A
- SLC6A4
- ADRA1A
- ADRA2C
- ADRA2B
- NR3C1
- MAOA
- TBXA2R
- MC3R
- MC4R
- MLNR
- NPY1R
- SLC6A3
- OPRD1
- SLC6A2
- PDE3A
- KCND3
- PGR
- PTGS2
- SAMHD1
- SLC29A1
- PDE4D
- ADORA1
- HTR3A
- HTR2C
- ADORA3
- ADRB3
- AGTR1
- AVPR1A
- AVPR2
- BDKRB2
- CCKAR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- ACM4
- ACM5
- CP2D6
- CP3A4
- CP3A7
- GLI3
- NR1I2
- TP53
Drug classes
- Cholinergic Muscarinic Antagonists
- Cholinergic Agents
- Cholinergic Antagonists
- Muscarinic Antagonists
- Neurotransmitter Agents
- Urological Agents
- Cholinergic Muscarinic Antagonist
ATC classes
Cross-references
Synonyms
- DARIFENACIN HYDROBROMIDE
- ENABLEX
- Enablex
- enablex
- darifenacin hydrobromide
- emselex
- Darifenacine
- Darifenacina
- Darifenacin extended release
- UK-88525
- UK88525
- Emselex
- UNII-APG9819VLM
- APG9819VLM
- CHEMBL1346
- CHEBI:391960
- darifenacine
- [3H]darifenacin
- NCGC00168775-01
- Darifenacin (USAN/INN)
- Darifenacinum
- Darifenacin [USAN:INN:BAN]
- Emselex (TN)
- Enablex (TN)
- Darifenacin [USAN]
- DARIFENACIN [MI]
- DARIFENACIN [INN]
- DARIFENACIN [VANDF]
- DARIFENACIN [MART.]
- SCHEMBL56574
- DARIFENACIN [WHO-DD]
- GTPL319
- GTPL321
- MLS003876823
- DTXSID2048290
- AMY40857
- HY-A0033
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