← SynDRA

LOMITAPIDE

SynDRA canonical compound SYN0005399 — structure-anchored drug synonym record

All known targets

• MTTP
• P4HB
• CYP2B6
• CYP2C19
• CYP2C8

Mechanisms of action (all sources)

• Microsomal trigylceride transfer protein inhibitor
• MTTP INHIBITOR
• Microsomal triglyceride transfer protein inhibitor
• P4HB INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• TBXA2R
• SLC6A2
• KCNH2
• ADORA3
• OPRM1
• DRD1
• DRD3
• CHRM1
• SLC6A3
• ADRA1A
• MTR
• MAOA
• PTGS1
• PGR
• PDE4A
• PDE3A
• SLC6A4
• ACHE
• KDR
• HTR1A
• HRH3
• HDAC6
• F2
• ESR1
• CHRM2
• AR
• ADRA2A
• HTR2B

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP2C9
• CP2D6
• CP3A7
• IFNG
• KSYK
• NSD2
• SYK

Drug classes

• Cytochrome P450 3A4 Inhibitors
• P-Glycoprotein Inhibitors
• Microsomal Triglyceride Transfer Protein Inhibitors
• Microsomal Triglyceride Transfer Protein Inhibitor

ATC classes

• C10A · LIPID MODIFYING AGENTS, PLAIN

Cross-references

• PubChem CID: 9853053
• ChEMBL: CHEMBL354541
• DrugBank: DB08827
• ChEBI: CHEBI:72297
• KEGG: D09637
• RxNorm: 1364479
• Wikipedia: Lomitapide
• TTD: D0H8VY
• LINCS BRD: BRD-K92213669

Synonyms

• JUXTAPID
• Juxtapid
• juxtapid
• BMS 201038
• lomitapide mesylate
• lojuxta
• lomitapide mesilate
• BMS201038
• Lomitapida
• AEGR-733
• BMS-201038-01
• Lojuxta
• AEGR733
• BMS 201238
• BMS 201038-01
• AEGR 733
• AEGR-733(Lomitapide)
• Lomitapide free base
• AEGR-733;BMS-201038
• CHEMBL354541
• CHEBI:72297
• 82KUB0583F
• 182431-12-5 (free base)
• Lomitapide [USAN]
• Lomitapide [USAN:INN]
• lomitapida
• lomitapidum
• UNII-82KUB0583F
• HSDB 8218
• LOMITAPIDE [MI]
• LOMITAPIDE [INN]
• Lomitapide (USAN/INN)
• LOMITAPIDE [VANDF]
• LOMITAPIDE [WHO-DD]
• AEGR773
• SCHEMBL304604
• AEGR-773
• GTPL7439

Reported adverse events

• Hepatic steatosis
• Abdominal discomfort
• Abdominal distension
• Abdominal pain
• Alopecia
• Chest pain
• Constipation
• Dizziness
• Dyspepsia
• Fatigue
• Flatulence
• Gastroenteritis