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3,5-DINITROCATECHOL (OR-486)
SynDRA canonical compound SYN0005390 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | COMT |
|---|
| Mechanism of action | catechol O methyltransferase inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- catechol O methyltransferase inhibitor
- COMT INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TTR
- NFE2L2
- HDAC6
- HIF1A
- HPGD
- HSD17B10
- KAT2A
- KDM4E
- KMT2A
- MAPK1
- MAPT
- MBNL1
- PMP22
- ALDH1A1
- POLH
- POLI
- POLK
- RAPGEF3
- RAPGEF4
- RECQL
- SLCO1B1
- SLCO1B3
- TDP1
- TRIM24
- GSK3B
- ABL1
- GMNN
- GLS
- ALOX12
- ALOX15
- APEX1
- ARSA
- ATXN2
- AURKA
- BAZ2B
- BRD4
- BRPF1
- CBX1
- CDK2
- CSNK1D
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADCY9
- ALR
- PRMT1
- PNMT
- PAFA2
- PAFA
- NTM1A
- NNMT
- MRGPRX1
- HNMT
- GSTO1
- GNMT
- GLSK
- GAMT
- DRD1
- DGLB
- CP2C9
- RPGF3
Drug classes
- Catechol O-Methyltransferase Inhibitors
Cross-references
Synonyms
- 3,5-Dinitrocatechol
- 3,5-dinitrobenzene-1,2-diol
- 3,5-Dinitro-1,2-benzenediol
- OR 486
- 3,5-Dinitropyrocatechol
- OR486
- UNII-VK0VA22GY2
- Pyrocatechol, 3,5-dinitro-
- 1,2-Benzenediol, 3,5-dinitro-
- BRN 2217246
- VK0VA22GY2
- CHEMBL168276
- 3,5-DINITRO-BENZENE-1,2-DIOL
- DNC
- SR-01000075610
- Ro 12812
- Ro 01-2812
- Tocris-0483
- Spectrum_000187
- Lopac-D-131
- AC1MZC4M
- Spectrum4_000747
- Spectrum2_001109
- Spectrum5_001163
- Entacapone EP Impurity E
- 3,5-Dinitrocatechol, solid
- Lopac0_000477
- RefChem:487074
- DTXCID00149882
- MFCD00069263
- OR486;OR-486
- 3,5-Dinitrocathecol
- 1,2-DIHYDROXY-3,5-DINITROBENZENE
- KBioGR_001074
- KBioSS_000667
- MLS002153481
- DivK1c_000067
- SPECTRUM1503631
- SPBio_001218
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