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TOLCAPONE
SynDRA canonical compound SYN0005279 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | COMT |
|---|
| Mechanism of action | Catechol O methyltransferase inhibitor |
|---|
All known targets
- COMT
- TTR
- Abcb11
- Comt
- GPR35
- KLF10
Mechanisms of action (all sources)
- Catechol O methyltransferase inhibitor
- COMT INHIBITOR
- Catechol O-methyltransferase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1A
- PTGS2
- NR1I2
- NR1H4
- KCNH2
- SLC6A3
- PGR
- ESR1
- NR1H3
- NR1H2
- NPY1R
- MC4R
- MLNR
- NR3C1
- MC3R
- MAOA
- KYAT3
- HTR3A
- HTR2C
- NR1I3
- OPRK1
- OPRD1
- RARG
- UGT1A9
- TDP1
- TBXA2R
- SLC6A4
- SLC6A2
- SLC29A1
- RARB
- HTR2A
- RARA
- PPARA
- PDXK
- PDE4D
- PDE3A
- OPRM1
- HTR2B
- ABCC2
- ABCC3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ALOX12
- ANDR
- PRGR
- PNMT
- NNMT
- LOX12
- KSYK
- IFNG
- HNMT
- GNMT
- GLI3
- GCR
- GAMT
- ESRRA
- ESR2
- CP3A7
- CP2C9
- SYK
Drug classes
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Catechol O-Methyltransferase Inhibitors
- Central Nervous System Agents
- Enzyme Inhibitors
- Catechol-O-Methyltransferase Inhibitor
ATC classes
- N04B · DOPAMINERGIC AGENTS
Cross-references
Synonyms
- TASMAR
- Tasmar
- RO 40-7592
- tasmar
- Tolcapona
- RO-40-7592
- RO-407592
- Roche brand of tolcapone
- Ro-40-7592
- Tasmar (TN)
- Tolcapone [USAN:INN]
- Tolcapone (JAN/USAN/INN)
- 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
- 3,4-dihydroxy-5'-methyl-5-nitrobenzophenone
- CIF6334OLY
- tolcapone (usp-rs)
- tolcapone (usp monograph)
- Ro 407592
- Ro 40 7592
- DTXCID903685
- 3,4-dihydroxy-5-nitro-4'-methylbenzophenone
- 4'-methyl-3,4-dihydroxy-5-nitrobenzophenone
- CHEBI:63630
- Tolcaponum
- Ro407592
- RefChem:57103
- N04BX01
- MFCD00866569
- s4021
- NCGC00181767-01
- Talcapone
- UNII-CIF6334OLY
- CCRIS 7904
- CAS-134308-13-7
- Tolcapone?
- MIQPIUSUKVNLNT-UHFFFAOYSA-N
- Tolcapone [USAN:USP:INN:BAN]
Reported adverse events
- Rhabdomyolysis
- Agitation
- Alopecia
- Arthritis
- Cataract
- Constipation
- Dizziness
- Dyskinesia
- Dyspepsia
- Dystonia
- Fall
- Fatigue
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