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DARUNAVIR
SynDRA canonical compound SYN0005272 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | HIV protease inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP3A4
- ABCB1
- CYP3A5
- HIV PR
- HIV-1 protease
- gag-pol
- pol
- protease
Mechanisms of action (all sources)
- protease inhibitor
- HIV PR MODULATOR
- pol INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- HTR2B
- TBXA2R
- SLC6A4
- SLC6A3
- SLC6A2
- SCN5A
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KCNH2
- KCND3
- HTR1A
- ADORA3
- HRH3
- HDAC6
- GMNN
- F2
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- CACNA1C
- AR
- ADRA2A
- ADRA1A
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- HIV Protease Inhibitors
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antiviral Agents
- Enzyme Inhibitors
- Protease Inhibitors
- Viral Protease Inhibitors
- Protease Inhibitor
- Cytochrome P450 2D6 Inhibitors
- Cytochrome P450 3A Inhibitors
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- PREZCOBIX
- PREZCOBIX PED
- PREZISTA
- Prezcobix
- Prezista
- SYMTUZA
- darunavir ethanolate
- prezista
- TMC 114
- darunavir ethnolate
- (-)-darunavir
- TMC-114
- TMC-41629
- TMC114
- UIC-94017
- UIC-940T
- Darunavir component of prezcobix
- Darunavir component of symtuza
- Darunavir krka
- Darunavir krka d.d.
- Darunavir viatris (previously darunavir mylan)
- UIC 94017
- Darunavirum
- Darunavirum [INN-Latin]
- UNII-YO603Y8113
- AIDS073035
- CHEMBL1323
- CHEBI:367163
- Darunavir-d9
- YO603Y8113
- NCGC00168773-01
- Darunavir [USAN]
- Prezista(TM)
- UIC-96017
- Darunavir (USAN/INN)
- TMC 41629
- (-)-DARUNAVIR
Reported adverse events
- Rash
- Hepatotoxicity
- Headache
- Fatigue
- Nausea
- Rhabdomyolysis
- Toxic epidermal necrolysis
- Asthenia
- Dyspepsia
- Vomiting
- Crystal nephropathy
- Abdominal distension
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