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ISOSORBIDE MONONITRATE
SynDRA canonical compound SYN0005222 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GUCY1A2 | GUCY1A3 | GUCY1B2 | GUCY1B3 |
|---|
| Mechanism of action | nitric oxide stimulant |
|---|
| Indication | angina pectoris | coronary artery disease (CAD) |
|---|
| Disease area | cardiology |
|---|
All known targets
- GUCY1A1
- GUCY1A2
- GUCY1B1
- GUCY1B2
- NPR1
- EGFR
- ESR1
Mechanisms of action (all sources)
- GUCY1B1 ACTIVATOR
- GUCY1A2 ACTIVATOR
- GUCY1A1 ACTIVATOR
- nitric oxide stimulant
- GUCY1B2 ACTIVATOR
- Guanylate cyclase stimulant
- EGFR ACTIVATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- NPY1R
- MC4R
- MC3R
- MAOB
- MAOA
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HDAC6
- HCAR2
- MLNR
- NPY2R
- GHSR
- NR3C1
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- PTGS2
- PTGS1
- PGR
- PDE4D
- PDE4A
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- NTSR1
- GIPR
- GCGR
- ADORA1
- CA2
Drug classes
- Nitrate Vasodilator
- Cardiovascular Agents
- Nitric Oxide Donors
- Vasodilator Agents
- Explosive Agents
- Anti-Asthmatic Agents
- Antioxidants
- Bronchodilator Agents
- Endothelium-Dependent Relaxing Factors
- Free Radical Scavengers
- Gasotransmitters
- Neurotransmitter Agents
ATC classes
- C01D · VASODILATORS USED IN CARDIAC DISEASES
- R07A · OTHER RESPIRATORY SYSTEM PRODUCTS
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Cross-references
Synonyms
- IMDUR
- ISMO
- MONOKET
- isosorbide-5-mononitrate
- isosorbide 5-nitrate
- monosorbitrate
- Mononitrate d'isosorbide
- Mononitrato de isosorbida
- Isosorbide dinitrate isosorbide-5-mononitrate
- 1,1-diureidisobutane
- Corangin
- Iso-5-mononitrate
- Isobutyldiurea
- Isobutylenediurea
- Isosorbide-5-mononitrate
- Isosorbide 5-nitrate
- Monocord
- AHR-4698
- BM-22.145
- BM 22.145IS 5-MNAHR-4698
- BM-22-145
- BM-22145
- IS-5-MN
- IS-5MN
- NSC-758619
- Angeze 10
- Angeze 20
- Angeze 40
- Angeze sr 40
- Angeze sr 60
- Angitate
- Astrodur mr
- Carmil xl
- Chemydur 60 xl
- Cibral 10
- Cibral 20
- Cibral 40
Reported adverse events
- Headache
- Vertigo
- Hypotension
- Syncope
- Palpitations
- Vomiting
- Nausea
- Tinnitus
- Abdominal discomfort
- Amblyopia
- Asthenia
- Chromaturia
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