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ROTIGOTINE
SynDRA canonical compound SYN0005153 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DRD5 |
|---|
| Mechanism of action | Dopamine receptor agonist |
|---|
| Indication | Parkinson's Disease | restless leg syndrome |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- DRD3
- DRD4
- DRD1
- DRD5
- ADRA2B
- HTR1A
Mechanisms of action (all sources)
- Dopamine receptor agonist
- DRD2 AGONIST
- D2-like dopamine receptor agonist
- DRD3 AGONIST
- DRD4 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2A
- SLC6A4
- HTR2B
- HRH1
- OPRM1
- SLC6A2
- SLC6A3
- KCNH2
- ADRA2A
- ADRA1A
- ADRA2C
- TBXA2R
- NR1I2
- UNG
- KDR
- MAOA
- TDP1
- MBD4
- MC3R
- MLNR
- MPG
- MUTYH
- NEIL1
- NEIL2
- NTHL1
- NR3C1
- OGG1
- OPRD1
- TDG
- HTR3A
- PDE4D
- PGR
- PPARG
- PTGS2
- S1PR1
- SLC29A1
- PDE3A
- ACHE
- HTR2C
- CHRNA4
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACES
- ACM1
- ANDR
- CP19A
- CP2C9
- CP2CJ
- CP2D6
- CP3A7
- GLI3
- PRGR
- TSHR
Drug classes
- Dopamine Agonists
- Dopamine Agents
- Neurotransmitter Agents
- Nonergot Dopamine Agonist
ATC classes
- N04B · DOPAMINERGIC AGENTS
Cross-references
Synonyms
- NEUPRO
- Neupro
- neupro
- leganto
- (S)-(-)-Rotigotine
- Rotigotina
- Leganto
- SPM-962
- (6S)-rotigotine
- UNII-87T4T8BO2E
- N-0923
- CHEMBL1303
- 87T4T8BO2E
- 99755-59-6 (free base)
- NCGC00168748-01
- Rotigotine CDS Patch
- DSSTox_CID_26772
- DSSTox_RID_81893
- DSSTox_GSID_46772
- C19H25NOS
- Rotigotine CDS
- CAS-99755-59-6
- Neupro (TN)
- Rotigotine [USAN:INN:BAN]
- SPM-936
- SPM-937
- PubChem16423
- GTPL941
- cc-129
- Rotigotine (JAN/USAN/INN)
- (-)-N-0437
- SCHEMBL1088585
- ZINC4028
- DTXSID5046772
- HSDB 8254
- CHEBI:135351
- HMS3885D17
- EX-A1164
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