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SALSALATE
SynDRA canonical compound SYN0005106 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | PTGS1 |
|---|
| Mechanism of action | NFKB pathway inhibitor |
|---|
| Indication | osteoarthritis | rheumatoid arthritis |
|---|
| Disease area | rheumatology |
|---|
All known targets
- PTGS1
- PTGS2
- ASIC3
- BACE1
- AKR1C1
- CA6
- CA12
- CA2
- CA4
- CA1
- SABP2
- CA9
Mechanisms of action (all sources)
- NFKB pathway inhibitor
- PTGS1 INHIBITOR
- Cyclooxygenase inhibitor
- Prostanoid receptor inhibitor
- Prostanoid receptor antagonist
- PTGS2 INHIBITOR
- ASIC3 MODULATOR
- beta-secretase inhibitor
- CA6 INHIBITOR
- CA12 INHIBITOR
- CA2 INHIBITOR
- CA4 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ACHE
- HTR2C
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- KDM4E
- KCNH2
- HTR6
- HTR2B
- MC5R
- HTR2A
- HTR1A
- HSD17B10
- HRH3
- HRH2
- HRH1
- HPGD
- HMGCR
- HDAC6
- MC4R
- MMP1
- FLT1
- PRKCA
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
- SIGMAR1
- PTPRC
- PTAFR
- PPP3CA
- MMP9
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Anti-Infective Agents
- Antifungal Agents
- Dermatologic Agents
- Keratolytic Agents
- Antidiarrheals
ATC classes
- N02B · OTHER ANALGESICS AND ANTIPYRETICS
- S01B · ANTIINFLAMMATORY AGENTS
- D01A · ANTIFUNGALS FOR TOPICAL USE
Cross-references
Synonyms
- Disalcid
- salicylic acid salicylate
- disalicylic acid
- salicyl salicylate
- salicyloxysalicylic acid
- salicyloylsalicylic acid
- salicylsalicylic acid
- sasapyrine
- Salsalato
- Sasapyrine
- Disalicyclic acid
- Salicylic acid, bimolecular ester
- Salicylsalicylic acid
- NSC-49171
- Diacesal
- Diplosal
- Disalicylsaeure
- Disalyl
- Nobacid
- Salflex
- Salical
- Salina
- Saloxium
- Salsalatum;Salysal
- Sasapirin
- Sasapyrin
- Sasapyrinum
- Disalicylic acid
- Sal Ester Sal
- Salicylic Acid Salicylate
- Salicyloylsalicylic acid
- Disalcid (TN)
- O-Salicylcylsalicylsaeure
- O-Salicyloylsalicylic Acid
- O-Salicylsalicylic acid
- Salflex (TN)
- Salicylic acid, salicylate
- Salsalato [INN-Spanish]
Reported adverse events
- Hypersensitivity
- Asthenia
- Dysuria
- Erythema
- Insomnia
- Constipation
- Dizziness
- Dyspareunia
- Flatulence
- Henoch-Schonlein purpura
- Hepatotoxicity
- Pancreatitis
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