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ADAPALENE
SynDRA canonical compound SYN0004947 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | RARG |
|---|
| Mechanism of action | Retinoid receptor agonist |
|---|
| Indication | acne vulgaris (AV) |
|---|
| Disease area | dermatology |
|---|
All known targets
- RARA
- RARB
- RARG
- GLRA1
- GOT1
- RXRA
- RXRB
- RXRG
Mechanisms of action (all sources)
- Retinoid receptor agonist
- RARG AGONIST
- Retinoic acid receptor agonist
- RARB AGONIST
- RARA AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- ADORA1
- OGG1
- NR5A1
- NR4A1
- NR3C1
- NR2E1
- NR2C1
- NR1I2
- NPY1R
- NEIL2
- NEIL1
- MLNR
- MC3R
- MBD4
- MAOA
- LMNA
- NTHL1
- OPRD1
- HTR3A
- SLC6A4
- UNG
- TST
- TDP1
- TDG
- TBXA2R
- SMUG1
- SLC6A3
- OPRK1
- SLC6A2
- SLC29A1
- PTGS2
- PDE4D
- PDE3A
- OPRM1
- KCNH2
- HTR2C
- ADORA2A
- HTR2B
- CHRM1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP19A
- ESR1
- GCR
- HSPB1
- HSPD1
- HSPE1
- KSYK
- NF2L2
- NR1H4
- SYK
- TP53
- UBP1
- USP10
- USP8
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Dermatologic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Retinoid
ATC classes
- D10A · ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Cross-references
Synonyms
- ADAPALENE AND BENZOYL PEROXIDE
- CABTREO
- Cabtreo
- DIFFERIN
- DIFFERIN EPIDUO
- Differin
- EPIDUO
- EPIDUO FORTE
- Epiduo
- differin
- Adapaleno
- CD-271
- Adapalene component of cabtreo
- Adapalene component of epiduo
- Adapalene component of idp-126
- Adaferin
- Adapalenum
- Differine
- CD271
- Adaferin (TN)
- Adapaleno [INN-Spanish]
- Adapalenum [INN-Latin]
- Differin (TN)
- Differin, Adapalene
- KS-1196
- Adapalene [USAN:BAN:INN]
- Adapalene (JAN/USAN/INN)
- MFCD03106112
- CHEMBL1265
- CHEBI:31174
- 1L4806J2QF
- NCGC00164617-01
- Adapalen
- Differin Gel
- CAS-106685-40-9
- Differin Gel 0.1%
- Adapalene [USAN:INN:BAN]
Reported adverse events
- Erythema
- Skin irritation
- Pruritus
- Eczema
- Skin burning sensation
- Hypersensitivity
- Dermatitis
- Dry skin
- Application site irritation
- Application site burn
- Dermatitis atopic
- Sunburn
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