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NAFTOPIDIL
SynDRA canonical compound SYN0004850 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | ADRA1A | ADRA1D |
|---|
| Mechanism of action | adrenergic receptor antagonist |
|---|
| Indication | benign prostatic hyperplasia (BPH) |
|---|
| Disease area | urology |
|---|
All known targets
- ADRA1D
- ADRA1A
- ADRA1B
- ADRB2
- Adra1a
- Adra1b
- Adra1d
- Adra2a
- Adra2b
- Adra2c
Mechanisms of action (all sources)
- ADRA1D ANTAGONIST
- Alpha-1d adrenergic receptor antagonist
- adrenergic receptor antagonist
- ADRA1A INHIBITOR
- ADRA1A ANTAGONIST
- ADRA1B ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- OPRM1
- NR3C1
- HRH1
- DRD3
- DRD2
- DRD1
- HRH2
- HTR1A
- HTR2A
- HTR2B
- SLC6A2
- SLC6A3
- SLC6A4
- ADRB1
- KCNH2
- OPRK1
- MTOR
- MPHOSPH8
- MC3R
- NR1I2
- MAPT
- MAPK1
- OPRD1
- PGR
- PDE3A
- PDE4A
- PDE4D
- LMNA
- PMP22
- POLI
- PTGS1
- PTGS2
- PTH1R
- RGS4
- SAMHD1
- SLC29A1
- SMAD3
- TBXA2R
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- AHR
- RARA
- NPY2R
- NPY1R
- MK01
- M3K3
- KCMB4
- KCMB1
- GPR32
- GLI3
- ESRRA
- ESR2
- CP2D6
- CP2CJ
- CAC1H
- ANDR
- YAP1
Drug classes
- Adrenergic Agents
- Adrenergic alpha-Antagonists
- Adrenergic Antagonists
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Hematologic Agents
- Membrane Transport Modulators
- Neurotransmitter Agents
- Platelet Aggregation Inhibitors
Cross-references
Synonyms
- BM-15275
- KT-611
- avishot
- flivas
- naftopil
- naftopidil hydrochloride
- naftopidil dihydrochloride
- naftopidil HCl
- Flivas
- NSC-759293
- Naftopidil [INN]
- Avishot
- Naftopidilum [Latin]
- Naftopidil (Flivas)
- Naftopidil (unspecified)
- BRN 0629965
- CHEMBL142635
- C24H28N2O3
- 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol
- NCGC00015718-06
- (+-)-1-(4-(2-Methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol
- 4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol
- (RS)-1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol
- DSSTox_RID_80725
- DSSTox_CID_25176
- Naftopidilum
- R9PHW59SFN
- NSC 759293
- DTXCID3025176
- RefChem:831691
- (+/-)-Naftopidil
- MFCD00242741
- SMR000466346
- CAS-57149-07-2
- UNII-R9PHW59SFN
- Avishot;
- Flivas (TN)
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